Synthesis, Characterization and Antidiabetic Study of Nd (III) Complex of 1-(p-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)Ethyl) Phenyl)Sulfonyl)-3-(trans-4-methyl Cyclohexyl) Urea Amaryl or Glimepiride, An Oral Antidiabetic Drug

Abstract

This paper deals with the synthesis and characterization of a glimepiride-neodymium complex, rare earth's metal. Glimepiride is an oral hypoglycemic agent. The conductometric titrations were conducted using monovariation method which shows the ligand metal ratio as 2:1. Molar conductance value indicate that complex is non-ionic in nature. Analytical results agree to the molecular formula (C 24 H 34 N 4 O 5 S) 2 Nd.4H 2 O. rare earth's element Nd shows the high coordination sites. The structure of the complex was assigned as hexagonal in which ligand moleculas joining the central Nd(III) atom with nH 2 O molecules. Infrared spectral studies have supported coordination of sulphonyl oxygen on one side and enolic oxygen attached from other side and four water molecule attached by four coordination sides with the neodymium ion. Mass spectral, thermal and magnetic studies supports structure of the complex proposed on the basis of analytical data X-ray diffraction studies.

X-ray Diffraction and Thermal Characterization Study of SmIII Complex of Sulphonylurea, Glipizide: An Oral Antidiabetic Drug

“…It has been reported that in biological activity metal complexes are more potent and less toxic as compared to the free ligand [13][14][15][16] . Recently, metals in medicine have been recognized internationally as an important area for research and much attention has been given to the use of sulphonylureas with inner transition metals because of their high complexing nature [17][18] .In this account, we have undertaken the Sm III metal complex of glipizide drug for study. The metal complex was characterised by using different physico chemical methods like elemental analyses (C, H, N, S and metal content), Scheme 1: Structure of Glipizide drug X-ray diffaractionand TGA techniques.…”