Glibenclamide is a current, potent hypoglycemic agent used in NIDDM (non-insulin dependent Diabetes mellitus). Metal complexs of glibenclamide has been synthesised by reaction with mercury (II) in the form of its chloride. The conductometric titration using monovariation method indicates that complex is non-ionic and ML 2 type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Analytical data agrees with the molecular formula (C 23 H 28 ClN 3 O 5 S) 2 Hg structure of the complex was assigned as tetrahedral in which ligand molecules lies horizontally joining the central mercury atom. Infrared spectral and molar conductance data confirm the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. Structure assigned to the complex is supported by analytical data, IR spectra and NMR spectra.

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Recently metals in medicine has been recognised internationally as an important area for research. In this account the role of rare earth's metal neodymium has been undertaken for study 7-10. In recent years, much attention is given to the use of suphonyl ureas because their high complexing nature with essential metals. Sulphonyl

This paper deals with the synthesis and characterization of a glimepiride-neodymium complex, rare earth's metal. Glimepiride is an oral hypoglycemic agent. The conductometric titrations were conducted using monovariation method which shows the ligand metal ratio as 2:1. Molar conductance value indicate that complex is non-ionic in nature. Analytical results agree to the molecular formula (C 24 H 34 N 4 O 5 S) 2 Nd.4H 2 O. rare earth's element Nd shows the high coordination sites. The structure of the complex was assigned as hexagonal in which ligand moleculas joining the central Nd(III) atom with nH 2 O molecules. Infrared spectral studies have supported coordination of sulphonyl oxygen on one side and enolic oxygen attached from other side and four water molecule attached by four coordination sides with the neodymium ion. Mass spectral, thermal and magnetic studies supports structure of the complex proposed on the basis of analytical data X-ray diffraction studies.

Man has been in continued search for chemotherapeutic agents right from the earliest times, about 2000 B.C. or even earlier. As a result of this research several naturally occurring substances, plant materials and minerals including Arsenic, Mercury, Bismuth, Gold and Silver as metals or as their salts have been used for several thousand years, especially in Ayurveda and Unani system of medicine. In the early part of the twentieth century, organo-metallic compounds emerged as important agents in the treatment of syphilis tropical diseases etc 1-3. The discovery of vitamin B 12 and copper phthalocyanine has given impetus to the development of metal complexes with organic ligands. Silver has been employed medicinally for several thousand years, but it came into prominence only after paracelsus recommended its use for diseases of the nervous system. Until late in the nineteenth century, silver nitrate (Lunarcaustic) was still employed for the treatment of epilepsy 4-7 .