Synthesis, Physicochemical, Spectral and Pharmacological Studies of Silver Complex of Glibenclamide, An Oral Antidiabetic Drug

Abstract

Man has been in continued search for chemotherapeutic agents right from the earliest times, about 2000 B.C. or even earlier. As a result of this research several naturally occurring substances, plant materials and minerals including Arsenic, Mercury, Bismuth, Gold and Silver as metals or as their salts have been used for several thousand years, especially in Ayurveda and Unani system of medicine. In the early part of the twentieth century, organo-metallic compounds emerged as important agents in the treatment of syphilis tropical diseases etc 1-3. The discovery of vitamin B 12 and copper phthalocyanine has given impetus to the development of metal complexes with organic ligands. Silver has been employed medicinally for several thousand years, but it came into prominence only after paracelsus recommended its use for diseases of the nervous system. Until late in the nineteenth century, silver nitrate (Lunarcaustic) was still employed for the treatment of epilepsy 4-7 .