Synthesis, characterization, and antimicrobial activity of novel (E)-1-(aryl)-3-{3, 5-dimethoxy-4-[(1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy]phenyl}prop-2-en-1-ones

Click chemistry beyond metal‐catalyzed cycloaddition as a remarkable tool for green chemical synthesis of antifungal medications

“…According to various research, their conjugation with the 1,2,3‐triazole demonstrated improved the antifungal activity of new conjugates. The 1,2,3‐triazolyl‐benzothiazole hybrids E′2 against M. phaseolina and E′4 against S. rolfsii , with ortho‐nitro substitution on phenyl triazolyl moiety of hybrid molecule, showed stronger antifungal activity than fluconazole (Subhashini et al., 2018). Conjugated compounds H′1–H′3 containing electron‐withdrawing substitutions such as halogen atoms and nitro group on benzyl ring attached to the triazole moiety showed better antifungal activity than fluconazole against A. niger (Deswal et al., 2020).…”

“…In another study, a series of 1,2,3‐triazolyl‐benzothiazole hybrids were synthesized from the reaction of 3,5‐dimethoxy‐4‐(propynyloxy)phenyl benzothiazole and different substituted aromatic azides using click chemistry. ZI assay of these hybrid molecules at 5 mg mL −1 concentration reflected that compounds E′1 – E′2 with the ZI = 34 and 35 mm against Macrophomina phaseolina and compounds E′3 – E′4 with ZI = 22 and 23 mm against Sclerotium rolfsii outperformed fluconazole with the ZI = 17 and 5 mm, respectively (Subhashini et al., 2018). Shareef et al.…”