Synthesis, Characterization and Antimicrobial Activity of First Row Transition Metal(II) Complexes of Novel Schiff Base Derived from Sulfapyridine and Pyridine-2-Aldehyde

Abstract

A new Schiff base ligand (N-pyridin-2-yl-4-[(pyridin-2-yl)methyl amino]benzene sulfonamide) (L) was prepared by the reaction between sulfapyridine and pyridine-2-aldehyde. The ligand is bidentate by coordinating through pyridinyl nitrogen and azomethine nitrogen atom with Co(II), Ni(II), Cu(II), Zn(II) and Mn(II) chlorides. The complexes were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, IR, H 1 NMR and electronic spectral data. These complexes were screened in vitro antibacterial activity against the test microorganisms Staphylococcus aureus, Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger. The results of these studies revealed that all complexes exhibit significant to moderate antimicrobial activity. aldehydes like indole-2-aldehyde and pyrrole-2-aldehyde are coupled with sulfa drugs the resulting compound sulfadrugimine can act as an effective antibacterial agent 10 . In the present investigation an attempt has been made to synthesize Schiff base by coupling pyridine-2-aldehyde and sulfapyridine and also its complexes with various first row transition metal chlorides. EXPERIMENTALAll the reagents and solvents used were of analar grade. All the metal(II) complexes were prepared by using corresponding metal chlorides. Microanalyses of carbon, hydrogen and nitrogen were carried out at SAIF, IIT, Madras, India. IR spectra were recorded as KBr pellets on a Shimadzu 8000 FTIR spectrophotometer in the range of 4000-400 cm -1 . 1 H NMR spectra of compounds were recorded with a Bruker Spectrospin Avance DPX-400 using TMS as internal standard and DMSO-d 6 as solvent. UV-visible spectra were obtained in DMF on a Perkin Elmer Lambda 35 spectrophotometer in the range of 190-1100 nm. Magnetic susceptibility measurements were carried out on solid compounds at National Institute of Technology, Trichy, India. Conductance measurements were studied using Elico conductivity bridge and dip type conductivity cell. Melting points were determined by using Elico melting point apparatus. In vitro antibacterial and antifungal screening were studied at Periyar Maniammai Pharmaceutical College, Trichy, India. Synthesis of Schiff-base ligand (L):A hot ethanolic solution of pyridine-2-aldehyde (0.0125 mol) was added to a

Synthesis, structure analysis, anti-bacterial and in vitro anti-cancer activity of new Schiff base and its copper complex derived from sulfamethoxazole

“…This band is shifted to a higher frequency (1649 cm −1 ) in the complex compared with those of the Schiff-base ligand showing the coordination of the imino-nitrogen 19 to the copper atom. This is further confirmed by the appearance of a new band at 410 cm −1 due to the ν(M-N) 20 band. The coordination through the phenolic oxygen after deprotonation is revealed by the disappearance of the ν(OH) phenolic band at 3504 cm −1 and the shift of phenolic ν(C-O) 21 …”

Insight into sulfapyridine degradation mechanism and antibacterial activity change using enhanced hydrolysis

“…Previous studies were observed that the SPY is very much effective against the Bacillus subtillis and Staphylococcus aureus bacteria 5 . The stable chelate ring structure form by the nitrogen of the azomethine group and the nitrogen of the pyridinyl ring has stronger antimicrobial activity 6 . The related literature reported that SPY showed almost no loss of antimicrobial activity during hydrolysis 7 …”

“…5 The stable chelate ring structure form by the nitrogen of the azomethine group and the nitrogen of the pyridinyl ring has stronger antimicrobial activity. 6 The related literature reported that SPY showed almost no loss of antimicrobial activity during hydrolysis. 7 Hydrolysis was the most common reactions in pollution degradation.…”