A new bidentate Schiff base ligand (HL 1 ), containing O,N donors was prepared by the reaction of sulfamethoxazole with 5-nitrosalicylaldehyde and characterized by elemental analysis, FT-IR, 1 H and 13 C NMR. The copper complex of this ligand was synthesised by treating DMF-ethanolic mixture solution of the ligand of two equivalents with one equivalent of copper acetate. The complex was characterized on the basis of UV, FT-IR, molar conductance, EPR, magnetic moment and single crystal X-ray diffraction. Interestingly, the crystal structure of the octahedral complex showed two solvent molecules (DMF) as ligands at their axial positions. The molar conductance data revealed that the complex is a non-electrolyte. The Schiff base and its copper complex have been investigated as anti-bacterial and anti-fungal agents against various microorganisms. The in vitro cytotoxicity tests of the ligand and its copper complex were carried out in two different human tumour cell lines, HCT-116 and MDA -MB -231. The cytotoxicity studies showed that the complex exhibited higher activity than cisplatin and carboplatin towards MDA -MB -231.

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A new Schiff base ligand (N-pyridin-2-yl-4-[(pyridin-2-yl)methyl amino]benzene sulfonamide) (L) was prepared by the reaction between sulfapyridine and pyridine-2-aldehyde. The ligand is bidentate by coordinating through pyridinyl nitrogen and azomethine nitrogen atom with Co(II), Ni(II), Cu(II), Zn(II) and Mn(II) chlorides. The complexes were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, IR, H 1 NMR and electronic spectral data. These complexes were screened in vitro antibacterial activity against the test microorganisms Staphylococcus aureus, Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger. The results of these studies revealed that all complexes exhibit significant to moderate antimicrobial activity. aldehydes like indole-2-aldehyde and pyrrole-2-aldehyde are coupled with sulfa drugs the resulting compound sulfadrugimine can act as an effective antibacterial agent 10 . In the present investigation an attempt has been made to synthesize Schiff base by coupling pyridine-2-aldehyde and sulfapyridine and also its complexes with various first row transition metal chlorides. EXPERIMENTALAll the reagents and solvents used were of analar grade. All the metal(II) complexes were prepared by using corresponding metal chlorides. Microanalyses of carbon, hydrogen and nitrogen were carried out at SAIF, IIT, Madras, India. IR spectra were recorded as KBr pellets on a Shimadzu 8000 FTIR spectrophotometer in the range of 4000-400 cm -1 . 1 H NMR spectra of compounds were recorded with a Bruker Spectrospin Avance DPX-400 using TMS as internal standard and DMSO-d 6 as solvent. UV-visible spectra were obtained in DMF on a Perkin Elmer Lambda 35 spectrophotometer in the range of 190-1100 nm. Magnetic susceptibility measurements were carried out on solid compounds at National Institute of Technology, Trichy, India. Conductance measurements were studied using Elico conductivity bridge and dip type conductivity cell. Melting points were determined by using Elico melting point apparatus. In vitro antibacterial and antifungal screening were studied at Periyar Maniammai Pharmaceutical College, Trichy, India. Synthesis of Schiff-base ligand (L):A hot ethanolic solution of pyridine-2-aldehyde (0.0125 mol) was added to a