Synthesis, characterization and antimicrobial activity of some substituted 1,2,3-triazoles

Synthesis of Isoxazole and 1,2,3-Triazole Isoindole Derivatives via Silver- and Copper-Catalyzed 1,3-Dipolar Cycloaddition Reaction

“…The aim of this present work focuses on the synthesis of N-heterocyclic compounds, namely the synthesis of substituted isoxazole and triazole derivatives, since an important number of compounds containing the isoxazole and the triazole scaffold are known to exhibit a variety of biological activities in the pharmaceutical [16] and medicinal areas [17]. Representative examples of synthetic drugs incorporating these motifs are Tazobactam I [18][19][20][21][22], Rufinamide II [23][24][25], phenylisoxazole derivatives III [26,27], and Bextra (Valdecoxib) IV [28][29][30].…”

Synthesis and evaluation of 1-alkyl-4-phenyl-[1,2,3]-triazole derivatives as antimycobacterial agent

“…In particular, when the reaction occurs between alkyl or aryl azides and terminal acetylenes, [1,2,3]-triazoles are obtained. [9][10][11][12][13][14][15][16][17][18][19][20][21] If the cycloaddition is thermally conduced, a 1:1 mixture of the 1,4 and 1,5-regioisomers of triazole is usually obtained. Various attempts to control the regioselectivity without much success were reported until the discovery of the copper(I)-catalyzed reaction in 2002, which exclusively yields the 1,4-disubstituted-[1,2,3]-triazole.…”

“…11 In the literature triazoles are described as antiplatelet agents, 12 dopamine D2 receptor ligands (related to Schizophrenia 13 ) anti-inflammatory, 14,15 and antimicrobial agents. [16][17][18] Based on the rationale above, the purpose of this study was to synthesize several 4-phenyl-[1,2,3]-triazole derivatives with small molar mass and test them for inhibition of the growth of M. tuberculosis H37Rv strain (ATCC 27294).…”

Crystal structure of ethyl 1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazole-4 carboxylate, C12H12ClN3O2

“…1,2,3-Triazoles are an important class of heterocyclic compounds due to their wide range of applications as pharmaceutical agents [5,6]. The diversity of chemical structures of the 1,2,3-triazole family and their useful biological activities made these compounds attractive targets in synthetic organic chemistry and many studies have been reported on the synthesis of these compounds [7][8][9].…”