Synthesis, Characterization and Antioxidant Studies of Quinazolin Derivatives

Abstract

AbSTRACT3-((4-(dimethylamino)benzylidene)amino)-2-methylquinazolin-4(3H)-one (3), 3-((4-hydroxybenzylidene)amino)-2-methylquinazolin-4(3H)-one (4), 2-methyl-3-(pyrrolidin-2-ylideneamino) quinazolin-4(3H)-one (5) and 3,3'-((1,4-phenylenebis(methanylylidene)) bis(azanylylidene))bis(2-methylquinazolin-4(3H)-one) (6) derived from 3-amino-2-methylquinazolin-4(3H)-one have been synthesized and characterized by elemental analysis, FT-IR, NMR techniques and screened to establish their potential as antioxidants against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Nitric oxide (NO) radical scavengers. The results revealed that synthesized compounds (5 and 6) are much higher than common antioxidants ascorbic acid and they showed excellent scavenging capacity against DPPH and Nitric oxide (NO). The synthesized compounds (3 and 4) demonstrated encouraging results comparable with ascorbic acid.

Experimental and Quantum Chemical Studies on the Corrosion Inhibition of Mild Steel By 2-((Thiophen-2-Ylmethylene) Amino)Benzenethio in 1M HCl

“…Mild steel coupons texture of C (0.21%), Si (0.38%), Mn (0.05%), P (0.09%), Al (0.01%), and Fe (99.21%) were utilized for weight loss investigations. The coupons were cleaned according to the standard procedure to be specific ASTM G1-03 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In a typical methodology, coupons were suspended volume 200 mL of a corrosive solution (in duplicate) to try or not of 2-((thiophen-2-ylmethylene) amino) benzenethiol.…”

Experimental and Quantum Chemical Studies on the Corrosion Inhibition of Mild Steel By 2-((Thiophen-2-Ylmethylene) Amino)Benzenethio in 1M HCl

“…Mild steel coupons texture of C (0.21%), Si (0.38%), Mn (0.05%), P (0.09%), Al (0.01%), and Fe (99.21%) were utilized for weight loss investigations. The coupons were cleaned according to the standard procedure to be specific ASTM G1-03 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In a typical methodology, coupons were suspended volume 200 mL of a corrosive solution (in duplicate) to try or not of 2-((thiophen-2-ylmethylene) amino) benzenethiol.…”

Quinazoline pharmacophore in therapeutic medicine

“…An array of quinazoline-2,4-dione Schiff bases were reported to possess over 50% inhibitory efficiency upon DPPH (IC50 = 25-50 μg/mL) and most of the compounds showed a dose dependent behavior in FRAP assay (Vagdevi et al, 2012). 2-Methyl-3-(pyrrolidin-2-ylidene amino)quinazolin-4(3H)-one was reported to be much higher in activity compared with ascorbic acid standard (Al-Azawi, 2016). It also served as a powerful and highly resourceful scavenger against DPPH and Nitric oxide (Al-Azawi, 2016).…”

“…2-Methyl-3-(pyrrolidin-2-ylidene amino)quinazolin-4(3H)-one was reported to be much higher in activity compared with ascorbic acid standard (Al-Azawi, 2016). It also served as a powerful and highly resourceful scavenger against DPPH and Nitric oxide (Al-Azawi, 2016).…”