Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole

Lin, Yan; Ong, Yih Ching; Keller, Sarah; Karges, Johannes; Bouchene, Rafika; Manoury, Éric; Blacque, Olivier; Müller, Joachim; Anghel, Nicoleta; Hemphill, Andrew; Häberli, Cécile; Taki, Aya C.; Gasser, Robin B.; Cariou, Kevin; Keiser, Jennifer; Gasser, Gilles

doi:10.1039/d0dt01107j

Cited by 14 publications

(9 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Albendazole is an oral, broad-spectrum, anthelmintic agent of the benzimidazole class that is commonly used in the treatment of trichinellosis, toxocariasis and other nematode infection in addition to echinococcosis and cysticercosis (Hong, 2018, Verma et al, 2018and Lin et al, 2020. Albendazole is more effective in early stage of trichinellosis than in late stage (Eid et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Swilam

Nasreldin²,

Abd-Elrahman³

et al. 2022

New Valley Veterinary Journal

View full text Add to dashboard Cite

Trichinella spiralis (T. spiralis) is one of the parasitic nematodes of a highly zoonotic importance. It infects various vertebrates, including human. In this study eighty (n =80) Swiss albino mice were experimentally infected by T. spiralis to assess the nematocidal activity of tannic acid (TA) and albendazole (ABZ) individually or in combination during the intestinal phase of T. spiralis. Mice were divided into 10 equal groups 8 mice for each, (control): noninfected but received saline, (ABZ): non-infected and treated with ABZ 50 mg/kg, (TA1000): non-infected and treated with TA1000 µg/ml, (TA2000): non-infected and treated with TA2000 µg/ml, (ABZ+TA2000): non-infected and treated with ABZ 50 mg/kg + TA2000 µg/ml , (TS): infected non treated, (TS+ABZ) group: infected and treated with ABZ 50mg/kg, (TS+TA1000): infected and treated with TA1000 µg/ml, (TS+TA2000): infected and treated with TA2000 µg/ml and (TS+ABZ+TA2000): infected and treated with ABZ 50mg/kg + TA2000 µg/ml. Mice were sacrificed at 7 th day post infection. Results demonstrated significant reductions in the adult worm count in TS+TA1000, TS+ABZ, TS+ TA2000 and TS+ABZ+TA2000 with efficacies of 91%, 92%, 92% & 99% respectively. Results were confirmed by histopathological examination of the targeted organs. The degree of necrosis was decreased in treated groups, associated with reduction in the percentage of eosinophils. Elevated concentrations of serum ALT, AST, and urea in the infected group were decreased in treated groups, while albumin and glucose were increased.It was concluded that the combined albendazole-tannic acid therapy had the highest effect on reducing parasite burden and restoring normal histological architecture.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Swilam

Nasreldin²,

Abd-Elrahman³

et al. 2022

New Valley Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…Helminths, also known as flukes, roundworms, and tapeworms, are parasitic worms that look like worms. Other anthelmintics are poorly absorbed via the gut, exposing the parasite to considerably higher anthelmintic concentrations than the host [1][2][3] . The term "anthelmintic" refers to a medicine used to treat parasitic worm infestations in animals.…”

Section: Anthelminticsmentioning

confidence: 99%

Developing the analytical methods for the assay of anthelmintics (Albendazole) and anti- tuberculosis agents (Ethionamide) by utilizing two CT reagents - iodine and picric acid

Savita¹,

Shrivastava²,

Kumar³

et al. 2022

ijhs

View full text Add to dashboard Cite

Introduction - Rifampin, isoniazid, pyrazinamide, and ethambutol are antitubercular drugs that have been licenced by the FDA for the treatment of Mycobacterium tuberculosis infections. Antitubercular medicines are drugs that are used to treat tuberculosis. The term "anthelmintic" refers to a medicine used to treat parasitic worm infestations in animals. This comprises both flat and round worms, such as flukes (trematodes) and tapeworms (cestodes) (nematodes). Aim of this study - The primary aim of this research is to develop and validate simple, fast, reliable, robustness and ruggedness analytical procedures for anthelmintics (ALB) and antitubercular (ETH) medicines. Material and Methods - Two CT reagents, iodine and picric acid, were used to produce two simple and somewhat sensitive Albendazole (ALB) and Ethionamide (ETN) techniques. The CT complex with the placebo blank had almost the same absorbance as the reagent blank, indicating that there was no interference by using Systronics model 166 digital spectrophotometer tools. Organic solvents were employed to dissolve all of the chemicals, which were of analytical reagent grade.

show abstract

Section: Introductionmentioning

confidence: 99%

“…15,16 In addition, extensive studies by Meggers et al and others have shown that the functionalization of bioactive organic molecules with an inert metal core can improve the affinity and selectivity of enzyme inhibitors. [17][18][19][20][21] With respect to SARS-CoV-2, high-throughput screening (HTS) identied the organoselenium compound Ebselen as an inhibitor of SARS-CoV-2 infection in Vero E6 cells with low micromolar activity. 22 Based on these results, other studies have sought to optimize the activity of Ebselen toward SARS-CoV-2, but with limited success.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole

Abstract: A series of new ferrocenyl and ruthenocenyl derivatives of the organic drug albendazole have been prepared and their activity against different helminths and protozoans assessed.

Cited by 14 publications

References 41 publications

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Developing the analytical methods for the assay of anthelmintics (Albendazole) and anti- tuberculosis agents (Ethionamide) by utilizing two CT reagents - iodine and picric acid

Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes

Contact Info

Product

Resources

About