Synthesis, Characterization and AntitumourActivity of Metal Complexes of 5‐Carboxy‐2‐Thiouracil

Abstract

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.

Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2‐(4‐Thiazolyl)Benzimidazole (Thiabendazole)

“…By now, platinum a containing antitumor drugs of a new generation, carboplatin, iproplatin and spiroplatin, have gained widespread application [8]. Recently, studies of antitumor properties of the complexes ofNi(|I), Mn(II), Co(II), Cu(II), Zn(II), Ru(II), Sn(II), Zr(II) and Ti(II) have been reported [9][10][11].…”

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

“…The uracil derivative has formed a six-membered chelate ring via the deprotonated amino group and the phenylsubstituted nitrogen atom of the azo group [52]. Metal complexes with 5-carboxy-2-thiouracil were synthesized by Singh et al [53]. The structure of complexes with 5-carboxy-2-thiouracil is given in Figure 28.…”

“…Donor Atom Metal Structure References Summary data on the structure of the complexes and the donor atoms involved in the coordination is given in Table 1. polymer structure with an octahedral geometry [23] elemental analysis, UV-Vis, IR-, Mass-and 1 H NMR spectroscopy N3 and O2 Th(II), Ce(II), Gd(II) [24] elemental analysis, spectral (vibrational, electronic, 1 All octahedron, except one planar-square structure of Co(II), Ni(II) and Cu(II) [39] IR and NMR spectroscopy S Pd(II), Pt(II) square planar or tetrahedral [45] elemental analysis, IR, UV-Vis, powder X-ray diffraction O and S Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) octahedral [53] 1.…”

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

“…The metal complexes of Cu(II), Ni(II), Co(II), Zn(II), Cd(II), Mn(II) with 5-carboxy-2-thiouracil have been screened against Sarcoma-180 tumor cells [48]. The results show that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.…”