Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir

Abstract

ABSTRACT.With the aim to improve and extend the antiviral activity of the antiherpic drug penciclovir, to a wider spectrum of viruses, we have synthesized and characterized new binary and ternary complexes of Pd(II) of formulae cis-(pen)2PdCl2 and cis-[(nucl)2Pd(pen)2]Cl, where nucl guanosine, inosine, cytidine or penciclovir. The characterization was mainly based on IR and 1H NMR spectroscopy, and the results showed that in all prepared complexes, penciclovir coordinates to the metal through N7. The far-i.r, spectrum of the complex cis-(pen)2PdCl2 conf'mned the cis-geometry around Pd(II). All the prepared complexes were markedly active against HSV-1 and HSV-2 strains, but not against thymidine kinase-deficient HSV-1 strains.

Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

“…In the 848 cm −1 absorption region, off-plane folds corresponded to C–H bonds [38]. The spectrum agreed with previously reported spectra [39]. Nucleoside analogues have common vibration regions, as demonstrated by the acyclovir FTIR spectra reported by Akimsheva et al (2019), including amines and cyclic amides [40].…”

Synthesis, characterization and in vitro cytotoxicity of the first palladium(II) oxalato complexes involving adenine-based ligands

“…The above mentioned complexes [Pd(hoen) 2 (ox)]Á½H 2 O and [Pd(clen) 2 (ox)] were tested for their antitumour activity, but they were found inactive on P388 (mice leukaemia) cells with the IC 50 values equal to 200 lM. Finally, it is necessary to mention some of the mononuclear palladium(II) complexes with purine-based N-donor ligands, such as trans-[Pd(nuo) 2 X 2 ]ÁxH 2 O (nuo = adenosine, guanosine, inosine, or xanthosine, X = Cl À or Br À ) [23], cis-[Pd(pen) 2 Cl 2 ] (pen = 2-amino-9-[4-hydroxy-3-(hydroxymethyl)-butyl]-6,9-dihydro-3H-purin-6-one, penciclovir) [24], trans-[Pd(ade) 2 -(bup) 2 ] (AdeH = adenine, bup = tri-n-butylphosphine) [25], or [Pd(guo) 2 (en)] 9H 2 O (en = ethylene-1,2-diamine) [26].…”