An optimization of coagulation and flocculation of kaolin suspension by a newly synthesized quaternized oil palm empty fruit bunch cellulose denoted as a 9QC was investigated using the central composite design of the response surface methodology. The influences of coagflocculant dosage, pH, and kaolin suspension on turbidity removal efficiency and sludge volume index responses were studied and assessed according to a 2 3 full factorial design. The developed quadratic models revealed that the overall optimum values to obtain the highest performance of the responses were 62.5 mg/L of coag-flocculant dosage, pH 7, and 1400 mg/L of kaolin concentration. The predicted optimum responses were found to be in close proximity to the observed responses. The coag-flocculating of river water using 9QC carried out at the optimum values showed encouraging results as compared to alum which is commonly used in drinking water treatment process.