Synthesis, characterization and application of antibacterial lactoferrin nanoparticles

Duarte, Larissa G.R.; Alencar, William M. P.; Iacuzio, Raiza; Silva, Nathália Cristina Cirone; Picone, Carolina Siqueira Franco

doi:10.1016/j.crfs.2022.03.009

Cited by 35 publications

(25 citation statements)

References 84 publications

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“…Fabrication of LF-based nanocarriers can specifically deliver drugs to the brain across the blood–brain barrier and extensively enhance the therapeutic efficacy of the encapsulated active molecules (Zhao and Yang, 2018 ; Agwa and Sabra, 2021 ). Therefore, LF may also be a promising molecule for cancer therapy and nanomedicine (Duarte et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial properties of lactoferrin: A bibliometric analysis from 2000 to early 2022

Xu¹,

Wang²,

et al. 2022

Front. Microbiol.

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BackgroundHere, a bibliometric and knowledge map analysis are used to analyze the research hot spots and development trends regarding the antibacterial effect of lactoferrin (LF). By looking for research hot spots and new topics, we provide new clues and research directions for future research.MethodsArticles and reviews regarding the antibacterial effect of LF were retrieved and from the Web of Science Core Collection (WoSCC) on 25 June 2022. CiteSpace and VOSviewer were used to conduct the bibliometric and knowledge map analysis.ResultsIn total, 8,292 authors at 2,151 institutions from 86 countries published 1,923 articles in 770 academic journals. The United States was the leader regarding research on the antibacterial effects of LF, while the Netherlands was a pioneer in conducting research in this field. The University of California system contributed the most publications. Bolscher JGM published most articles, while Wayne Bellamy had most cocitations. However, there was insufficient cooperation among the various institutions and authors. BioMetals published most LF-antibacterial activity-related articles, whereas Infection and Immunity was most commonly cocited journal. The most influential research hot spots about the antibacterial effect of LF focused on antimicrobial peptides, casein, human milk, expression, and Escherichia coli-related research. The latest hot spots and research frontier included COVID-19, antibiofilm activity, and immune defense.ConclusionsLF is a multifunctional protein with a broad spectrum of antimicrobial activities. The related field of antibacterial properties of LF will remain a research hot spot in future.

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Section: Discussionmentioning

confidence: 99%

Antibacterial properties of lactoferrin: A bibliometric analysis from 2000 to early 2022

Xu¹,

Wang²,

et al. 2022

Front. Microbiol.

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“…FT-IR spectroscopy analyses were carried out by the Nicolet 6700 spectrometer (Thermo Fisher, USA) with a diamond ATR (attenuated total reflectance method) accessory under the method described by Yu et al (2022) and Duarte et al (2022) with some modifications. The samples were scanned at a resolution of 4 cm −1 and full wavelength (650-4000 cm −1 ) with 32 scans.…”

Section: Methodsmentioning

confidence: 99%

Wheat gluten proteins phosphorylated with sodium tripolyphosphate: Changes in structure to improve functional properties for expanding applications

Zou

Zhang

et al. 2022

Current Research in Food Science

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“…Only 6 studies were found for lactoferrin delivery by polymeric particles. LF and gellan gum was combined through electrostatic complexation to enhance the antimicrobial properties of LF (Duarte et al 2022 ). Fabrication of LF-gellan gum complexes was done by mixing vacuum-filtered stock solutions of LF and gellan gum at pH 4—the pH at which the greatest net charge difference between the biopolymers was observed.…”

Section: Polymeric Micro- and Nanoparticlesmentioning

confidence: 99%

“…The LF-gellan gum complexes were characterized by zeta potential, isothermal titration calorimetry, FTIR, atomic force microscopy and minimum inhibitory concentration (MIC) assays to assess antimicrobial activity against S. aureus and E. coli . Duarte et al ( 2022 ) found that LF-gellan gum complexes reduced the MIC for S. aureus compared to free LF, however the effect was reduced in tryptic soy broth, which contained higher concentrations of divalent cations—Fe 2+ , Mn 2+ , Zn 2+ , Cu 2+ that competed with LF for anionic sites on the microbial membranes (Duarte et al 2022 ). The study also reported that complexation to gellan gum reduced the flexibility of LF, which may limit its interaction with bacterial membranes.…”

Section: Polymeric Micro- and Nanoparticlesmentioning

confidence: 99%

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

2022

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Bone and joint infections are a rare but serious problem worldwide. Lactoferrin’s antimicrobial and antibiofilm activity coupled with its bone-regenerating effects may make it suitable for improving bone and joint infection treatment. However, free lactoferrin (LF) has highly variable oral bioavailability in humans due to potential for degradation in the stomach and small intestine. It also has a short half-life in blood plasma. Therefore, encapsulating LF in nanocarriers may slow degradation in the gastrointestinal tract and enhance LF absorption, stability, permeability and oral bioavailability. This review will summarize the literature on the encapsulation of LF into liposomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric micro and nanoparticles and hydroxyapatite nanocrystals. The fabrication, characterization, advantages, disadvantages and applications of each system will be discussed and compared.

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Synthesis, characterization and application of antibacterial lactoferrin nanoparticles

Cited by 35 publications

References 84 publications

Antibacterial properties of lactoferrin: A bibliometric analysis from 2000 to early 2022

Antibacterial properties of lactoferrin: A bibliometric analysis from 2000 to early 2022

Wheat gluten proteins phosphorylated with sodium tripolyphosphate: Changes in structure to improve functional properties for expanding applications

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

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