Synthesis, characterization and bioactivity of thio-acetamide modified ZnO nanoparticles embedded in zinc acetate matrix

Abstract

ZnO nanoparticles embedded in zinc acetate matrix were synthesized by chemical route. The effect of thio-acetamide concentration during its synthesis was probed by structural, morphological, optical and bioactivity studies. XRD characterization indicated the formation of dominant phase of zinc acetate along with the low intensity peak of wurtzite ZnO. Morphological transition from bulky-like feature to flower-like feature via flake-like feature, is evidenced with increasing thio-acetamide molar concentrations. The optical band gap of samples decreased from ∼3.29 to 3.24 eV whereas the emitted color shifted from near green to blue region with increasing of molar concentration of thio-acetamide from 0 to 30% in the sample. The nanoparticles exhibited antimicrobial activity against seven (7) common human pathogenic bacteria including drug resistant varieties K. pneumonaie and S. aureus. The nanoparticles formed pores in the biological model membranes made from egg-phosphatidyl choline. Our study reveals that the thio-acetamide modified ZnO nanoparticles embedded in zinc acetate matrix could be used as potential drug lead to fight drug resistance against K. pneumoniae and S. aureus.

Chemical fabrication, structural characterization and photocatalytic water splitting application of Sr-doped SnO2 nanoparticles

“…Furthermore, on the transmission spectra, Kubelka-Munk equation was employed to calculate the band gap as: F(R)=α/s=(1 − R) 2 /2R; the terms in the above equation like F(R), α, s and R denote the Kubelka-Munk function, absorption coefficient, scattering factor, and reflectance of the as-synthesized SnO 2 and Sr-doped SnO 2 nanostructures, respectively. An intercept of the Taucs plot between αhυ 2 on y-axis and hυ on x-axis as shown in figure 9 provides the values of the band gap of as-synthesized materials [43][44][45]. The band gap values were found to be 3.56 eV, 3.54 eV, 3.12 eV and 3.03 eV for pure SnO 2 , 1%, 2.5% and 5% Srdoped SnO 2 nanoparticles, respectively.…”

Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives

“…Conjugation methods involve surface modification of the nanoparticles or entrapping them within polymer nanostructures or nanoparticles, either during or after nanoparticle fabrication [ 35 , 150 ]. For instance, surface modification of ZnO nanoparticles using ethanethioamide (C 2 H 5 NS) has been shown to improve the particles’ antibacterial bioactivity, resulting in the formation of a floral-like structure when ethanethioamide is mixed with the metal salt at the first stage of the reaction [ 151 ]. Additionally, researchers employed vinyl triethoxysilane (VTES) to prepare surface-modified ZnO nanoparticles, leading to reduced particle aggregation and slightly larger crystalline structures compared to pure nanoparticles [ 152 ].…”