2011
DOI: 10.1016/j.actbio.2011.07.011
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Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) hydrogels

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Cited by 49 publications
(39 citation statements)
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“…[24][25][26][27] Additionally, PEOz can be synthesized easily by the living cationic ring-opening polymerization of 2-ethyl-2-oxazoline and has been approved by the US Food and Drug Administration as food additive. 28 More significantly, PEOz has a favorable pK a , 29 and can be ionized at endo/lysosomal pH. 30 Our previous work and other report demonstrated that this property of PEOz promoted the release of drugs from micelles at the acidic endocytic pH in which PEOz composed the outer shell.…”
Section: Introductionmentioning
confidence: 97%
See 1 more Smart Citation
“…[24][25][26][27] Additionally, PEOz can be synthesized easily by the living cationic ring-opening polymerization of 2-ethyl-2-oxazoline and has been approved by the US Food and Drug Administration as food additive. 28 More significantly, PEOz has a favorable pK a , 29 and can be ionized at endo/lysosomal pH. 30 Our previous work and other report demonstrated that this property of PEOz promoted the release of drugs from micelles at the acidic endocytic pH in which PEOz composed the outer shell.…”
Section: Introductionmentioning
confidence: 97%
“…These were in good agreement with our previous report. 28 In FTIR spectra of PEOz-COOH ( Figure 3F(a)), the band at 1652 cm −1 was characteristic for the carbonyl vibration of the amide groups. 30 The band at 1736 cm −1 was attributed to the characteristic carbonyl absorption of the terminal carboxyl group.…”
Section: Introductionmentioning
confidence: 98%
“…Liu and co-workers reported that coupling of a similar type of semitelechelic diblock copolymer, namely OH-endcapped pEtOx-block-poly(lactic acid), with adipoyl chloride as a coupling agent yielded pEtOx-block-poly(lactic acid)-block-pEtOx triblock copolymers that showed temperature-dependent sol-gel-sol transition in water and possessed low cytotoxicity and good biocompatibility [66]. Similarly, Tarvainen and co-workers used OxOx for the coupling of two equivalents of poly(lactic acid), yielding poly(ester amide) copolymers that showed faster hydrolytic degradation for drug release compared to poly(lactic acid) homopolymers [67] (Scheme 4).…”
Section: Poly(2-oxazoline)-co-poly(lactid)smentioning
confidence: 99%
“…The in vitro cytotoxicity of various PTX-loaded micelles to PC-3 cells was evaluated as previously reported [28,29] except that the tested samples were incubated with PC-3 cells for 72 h.…”
Section: In Vitro Cytotoxicity Assessmentmentioning
confidence: 99%