Synthesis, characterization and biological activities of homo-binuclear Cu(II) and Zn(II) complexes derived from 2-hydroxy-5-methyl-1,3-benzenedicarboxaldehyde derivatives

Abstract

The data suggest that BHEM/BDEM/BTEM ligands afford square-pyramidal/distorted square-pyramidal geometry on metalation with Zn(II)/Cu(II). The binding behaviour of these complexes with DNA has been investigated using electronic absorption spectroscopy as well as viscosity and voltammetric measurements; the results show that they interact with DNA through intercalating way. From the DNA cleavage study of these complexes, investigated by gel electrophoresis, we found that they efficiently cleave supercoiled pUC19 DNA in the presence of a reducing agent (3-mercaptopropionic acid) and on irradiation with UV light of 360 nm wavelength. The mechanism reveals that singlet oxygen ( 1 O 2 ) plays a significant role in the photo cleavage. The superoxide dismutase (SOD) mimetic activity of the synthesized complexes demonstrates that most of the complexes have promising SOD-mimetic activity. The antimicrobial study indicates that the complexes inhibit the growth of bacteria and fungi more than the free ligands. Warsaw and Springer-Verlag Berlin Heidelberg. © Versita

Synthesis, structural features and biochemical activity assessment of N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

“…The electronic absorption spectrum of Cu(II) complex (3) displayed an absorption band at 533 nm, which is attributed to 2 B 2g → 2 A 1g transition, which confirmed the recommended square planar geometry for Cu(II) complex. Moreover, the observed μ eff value of Cu(II) complex was 1.80 B.M, consisting with one unpaired electron found in square planar Cu(II) complexes . Finally, the diamagnetic Zn(II) complex (4) does not show any absorption bands in the visible region and just showed a broad band at 394 nm which were mainly assigned to an S → Zn(II) charge transfer, not surprisingly for d 10 ions.…”

Recent Advances of Sensitive Electroanalytical Tools and Probes in the Study of DNA Structure

“…Raman et al [49] synthesized and characterized by analytical and spectral data the DNA-binding and cleavage properties of a binuclear Schiff base metal complexes [M 2 LCl 3 ], where M=Cu(II) and…”

Water-Soluble Monochloroplatinum(II) Complexes with Amino Acid Derived Schiff Bases as Ligands: Synthesis, Characterisation and Antitumour Activity

“…Although there are numerous reports on transition metal complexes of Schiff bases derived from amino * Correspondent. E-mail: llj@hbu.edu.cn acids, [6][7][8][9] there is little information on the corresponding derivatives of platinum(II). 10,11 We have prepared a series of L-amino acid Schiff bases coordinated to platinum(II).…”