Synthesis, characterization and biological activity of transition metal complexes with Schiff bases derived from 2-nitrobenzaldehyde with glycine and methionine

Singh, Brajesh Kumar; Rajour, Hemant K.; Prakash, Anant

doi:10.1016/j.saa.2012.03.077

Cited by 50 publications

(17 citation statements)

References 33 publications

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“…Overall, the outside groove binding is characterized by no or minor change in UV-Vis. spectra [35,36]. (Table 5) suggest that the complex binds to DNA through intercalation.…”

Section: Dna Binding and Cleavge Activitymentioning

confidence: 99%

Synthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligand

Dhanaraj¹,

Hassan

Johnson³

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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“…Overall, the outside groove binding is characterized by no or minor change in UV-Vis. spectra [35,36]. (Table 5) suggest that the complex binds to DNA through intercalation.…”

Section: Dna Binding and Cleavge Activitymentioning

confidence: 99%

Synthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligand

Dhanaraj¹,

Hassan

Johnson³

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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“…Molecular modeling was used to have an insight into the structural information of complexes in the absence of crystal structure data. Energyminimized configurations of complexes were achieved by the applications of molecular mechanics, which have become tools of increasing utility for the structural investigation of metal complexes [31,[59][60][61]. Molecular geometry is altered by energy minimization to lower the energy of the system.…”

Section: Molecular Modelingmentioning

confidence: 99%

Copper(II), nickel(II), and ruthenium(III) complexes of an oxopyrrolidine-based heterocyclic ligand as anticancer agents

Wani

ALOthman

Ali

et al. 2014

Journal of Coordination Chemistry

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An oxopyrrolidine-based ligand [3-(4-chlorobenzylidine)-5-(5-amino-1,3,4-thiadiazol-2-yl)pyrrolidin-2-one] was synthesized by coupling pyroglutamic acid with p-chlorobenzaldehyde followed by cyclization with thiosemicarbazide in presence of oxyphosphoryl chloride. Copper, nickel, and ruthenium complexes of the ligand were also synthesized. The electrolytic nature, with octahedral geometries for nickel and ruthenium complexes, was observed, while tetragonally distorted octahedral geometry for copper complex was proposed. The complexes were resistant to dissociation and degradation in 5% DMSO solutions of PBS (pH 7.4). DNA binding constants (K b ) for ligand, copper, nickel, and ruthenium complexes were 1.15 × 10 5 , 1.67 × 10 5 , 1.87 × 10 5 , and 1.007 × 10 6 M −1 , respectively, indicating quite strong binding with DNA. In silico studies also showed that the ligand interacted with DNA mainly through van der Waal's forces. The docking energy of ligand−DNA adduct was -30.45 kJ M -1 , suggesting a good affinity of the reported ligand with DNA. Both the ligand and its complexes were less toxic to RBCs as compared to doxorubicin. All the compounds showed moderate anticancer activities on MCF-7 (wild type) breast cancer cell lines.

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“…This d-d transition is very useful to predict the geometry of the metal complexes. In band is observed at 670 and 610 nm, respectively, because of 2 A 1g 2 B 1g and 1 A 1g 1 A 2g transitions, which confirm the square planar geometry of the metal complexes [24]. These shifts greatly support the coordination of ligand (H 2 L) to the metal centre.…”

Section: Uv-vis Spectroscopymentioning

confidence: 59%

Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies

Arun¹,

Packianathan²,

Malarvizhi³

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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Synthesis, characterization and biological activity of transition metal complexes with Schiff bases derived from 2-nitrobenzaldehyde with glycine and methionine

Cited by 50 publications

References 33 publications

Synthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligand

Synthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligand

Copper(II), nickel(II), and ruthenium(III) complexes of an oxopyrrolidine-based heterocyclic ligand as anticancer agents

Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies

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