Synthesis, Characterization and Biological Activity of Ni(II), Cu(II) and Fe(III) Complexes Derived from N2,N6-bis(5-Mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide

Abstract

Novel metal complexes of the type [M(L)X] (where M= Cu(II), Ni(II) and Fe(III), L = N2,N6-bis(5-mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide, X= Cl−, CH3COO−) were synthesized by the reaction of pyridine-2,6-dicarboxylic acid and 2-amino-5-mercepto-1,3,4-thiadiazole. The synthesized ligand was reacted in THF with metal salts (Cu, Ni and Fe) to form complexes. Deprotonated ligand shows tridentate nature and coordinate to metal ion to form pincer cavity. In all, complexes metals were surrounded by three nitrogen atom and other site coordinated by other groups (chloride, acetate). All the synthesized complexes were characterized by spectroscopic techniques like UV-visible, 13C NMR and 1HNMR, IR spectroscopy, DSC, elemental analysis and molar conductance measurements. The ligand and its metal complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity and antifungal activity when tested against bacteria and fungi

Synthesis of N2, N6-bis(5-methylthiazol-2-yl)pyridine-2,6-dicarboxamide fluoroscent sensor for detection of Cu2+ and Ni2+ Ions

“…The 1 HNMR spectra showed one broad singlet for the NH at δ 12.13 in CDCl 3 (▶Fig. 4) [47,48]. Moreover, expected Coupling between the protons is also clearly visible.…”

Synthesis and Structural Characterization of Pyridine-2,6-dicarboxamide and Furan-2,5-dicarboxamide Derivatives

“…This applies mainly to those heterocyclic systems for which some medical or pharmacological activity has already been demonstrated, but their use is still limited due to some structural constraints [ 1 ]. The exploitation of multiple binding sites of the pyridine-2,6-dicarboxamide and furan-2,5-dicarboxamide scaffolds makes it possible for the design of various functional materials [ 2 , 3 ], such as sensors [ 4 , 5 ], coordination sites [ 6 , 7 ], structural and functional models of proteins [ 8 , 9 ], derivatives with catalytic and biological activities [ 10 , 11 , 12 ], derivatives with antibacterial activities [ 13 , 14 ], etc. Pyridine-2,6-dicarboxamide is a chelating ligand for metal cations (Cu, Co, Fe, Ni, Pd), small anions (halides, phosphates and acetates), as well as small not-charged molecules (for example, urea) [ 1 ].…”