Synthesis characterization and biological evaluation of some alkoxyphthalimide derivatives of 3-(4-substituted phenyl)-6,6-diphenyl-3,3a-dihydro-2H-imidazo[2,1-b]pyrazolo[3,4-d][1,3]thiazol-7(6H)-one

Abstract

A series of 2-N-ethoxyphthalimido 3-(4-substitutedphenyl)-6,6-diphenyl-3,3a-dihydro-2H-imidazo[2,1-b] pyrazolo[3,4-d][1,3]thiazol-7(6H)-one(7a-e) and 4-(4-substituted phenyl)-2-(N-ethoxyphthalimido amino)-7,7-diphenylimidazo[2 0 ,1 0 :2,3][1,3]thiazolo[4,5-d] pyrimidin-8(7H)-one (9a-e) have been designed and synthesized starting from thiohydentoin (1). The structure of all synthesized compounds has been established by IR, 1 H NMR, 13 C NMR and mass studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.

Design and Synthesis of Imidazo[2,1‐b]thiazole–Chalcone Conjugates: Microtubule‐Destabilizing Agents

“…Due to its structural simplicity, ease of synthesis, and potent antitumor activity, this class of molecules is widely studied to find potent anticancer agents. [11][12][13] Recently, conjugates bearing imidazo [2,1-b]thiazole scaffolds have become of interest due to their broad spectrum of pharmacological activities, such as antifungal, [14,15] antibacterial, [16][17][18] anti-inflammatory, [19] and antihypertensive properties. [20] It has been reported that they possess antitumor properties against a variety of human cancer cell lines.…”

Synthesis and Applications of Imidazothiazoles: An Overview

“…Imidazothiazole core exhibits well-known therapeutic properties such as antitumor, [1][2][3][4] antihelminthic, [5][6] fungicide, [7][8][9] cardiotonic, [10] anti-hypertensiv, [11] anti-inflammatory, [12] antibacterial, [13][14][15][16][17][18] antiparasytic, [19] antiviral , [20] anti-oxidant [21] etc.…”

Synthesis of Pyrazolo[1,5‐a][1,3,5]triazine, Pyrazolo[1,5‐a]pyrimidine, and Imidazo[1,2‐b]pyrazole Derivatives Based on Imidazo[2,1‐b]thiazole Moiety

“…Also, imidazo[1,2‐ b ]pyrazole‐type derivatives are an important class of compounds in the medicinal field, with biological applications including anticancer . On the other hand, imidazo[2,1‐ b ]thiazoles occupy a great place in medicinal chemistry because of their broad spectrum of pharmacological activities, including antitumor activities against a variety of human cancer cell lines , as well as anti‐inflammatory , antibacterial , and antifungal activities .…”