Synthesis, characterization, and biological properties of rhenium(I) tricarbonyl complexes bearing nitrogen-donor ligands

Temperature Dependent Emission Properties of ReI Tricarbonyl Complexes with Dipyrido-Quinoxaline and Phenazine Ligands

“…In order to get further insights on the nature of II and its temperature-dependent population in the investigated complexes, the optimized geometries for the ground state, S 1 , T 1 , T 2 and T 3 excited states of all complexes were obtained by TD-DFT. The predicted S 0 geometry for all complexes are in good agreement with single crystal data, 10,33 where the maximum average error found for bond lengths were of 4.60%, and 3.92% for bond angles, which supports the further use of PBE0 in subsequent investigations. Then, spin-orbit coupling (SOC) matrix elements between the first 5 singlet and triplet states were calculated on top of the S 1 geometry.…”

“…[1][2][3][4] Such properties have been successfully applied in the development of light-emissive devices (LEDs), biomarkers, ion sensors, among other technological applications. [5][6][7][8] In fluid solution and in biological environments, the typical long-lived emitting states of Re I polypyridyl complex have been consistently employed as specific biological probes, [9][10][11][12] and for sensing of molecular oxygen and other triplet ground state molecules. [13][14][15] In more constrained media such as in polymeric matrixes, [16][17][18][19] variable photophysical behavior is observed as a function of the ligand structure and the specific linkage with the matrix.…”

The role of substituted pyridine Schiff bases as ancillary ligands in the optical properties of a new series of fac-rhenium(i) tricarbonyl complexes: a theoretical view

“…Complexes based on a Re(I) tricarbonyl core with a dinitrogenated ligand (N,N such as 1,10-phenanthroline or 2,2 0 -bipyridine derivatives) in the equatorial position, and halogen or pyridine derivatives as ancillary ligands (X), have been extensively used for diverse applications, including solar cells, 1,2 catalysis, [3][4][5][6][7][8] and more recently, biological applications, [9][10][11][12][13][14][15][16][17] including staining of bacteria, yeasts (walled cells), and proteins separated by SDS-PAGE. 18,19 Photophysical attributes of fac-[Re(I)(CO) 3 (N,N)X] n complexes (where n is 0 or 1+) can be modulated by combining the (N,N) and X ligands.…”

Exploring Ovarian Cancer Cell Resistance to Rhenium Anticancer Complexes

“…[14][15][16][17][18][19][20] Our lab has been studying the biological and anticancer activity of rhenium-based compounds,i np art because they are not cross-resistant with the conventional and widely used platinum-based drugs. [12,13,[21][22][23] Among the com-pounds that we have investigated, TRIP (Scheme 1) was found to be equally as effective as cisplatin in the A2780 ovarian cancer cell line.F urthermore,T RIP operates via ad istinct mechanism of action by inducing ER stress, activating the UPR pathway,a nd subsequently initiating apoptosis.B yc ontrast, the platinum-based drugs form covalent adducts on DNAa nd inhibit transcription. TheE R stress induction by TRIP was also different from that of other ER stress-inducing agents,s uch as the proteasome inhibitors bortezomib and carfilzomib, [24] the heat-shock protein 90 inhibitor geldanamycin, [25] or the SERCA pump inhibitor thapsigargin.…”

“…These complexes were chosen to probe the effects of different structural modifications on their susceptibility to TRIPresistance mechanisms.T he compound Neo-Re,[ Re(CO) 3 -(dmphen)(OH 2 )] + , [22] which contains an axial water ligand, is somewhat cross-resistant with TRIP;i ts RF is 4( Figures 2b and S6, SI). Additionally,t he compound Re-py,[ Re-(CO) 3 (1,10-phenanthroline)(pyridine)] + ,which was previously shown to have poor anticancer properties, [23] (Re-dmphen-pClICN), where pClICN = para-chlorophenyl isonitrile,w hich both contain axial isonitrile ligands like TRIP,exhibit only a3 -fold and 2fold decrease in activity in A2780TR cells,r espectively (Figures 2b,S 8a nd S9, SI). Collectively,t hese results show that subtle structural modifications on the rhenium tricarbonyl complexes can alter their sensitivity to the TRIPresistance mechanisms in the A2780TR cell line.A lthough the direct relationship between these structures and crossresistance to TRIP is not entirely clear, this observation does demonstrate that resistance to rhenium-based anticancer agents may be overcome by implementing minor structural modifications.…”