Synthesis, Characterization and Biological Screening of Cu (II)-3-Formylchromone Derivative Complex

Abstract

The complex of 3-formyl chromone derivative ligand with the Cu(II) complex was isolated in the solid form. Which have been characterized using FTIR spectrums. The FTIR spectrum shows bands for characteristic frequencies at 1604 cm-1 indicates C=O group, belongs to pyrone ring. The frequency at 510 to 596 cm-1 and band at 916 to 964 cm-1 indicates the M-O and M-O=C-in pyrone ring respectively. The UV-Vis spectroscopy shows that carbonyl of aldehyde group and carbonyl of pyrone ring of chromone of ligand shows n-π*and π-π* transition and complex shows electronic absorption at 369nm due to the 2 B 1 g → 2 B 2 g transition. Thermo Gravimetric Analysis (TGA) of complexes and ligand was carried out to determine the procedural and decomposition temperatures. The temperature range in which decomposition occurs in the range between 209°C to 350°C. The magnetic properties were determined from Gouy balance method. The number of unpaired electron found in complex of Cu(II)-3-formylchromone derivative was one and it has dsp2 hybridization. The complex is soluble in DMSO. The molar conductance of the complex are measured in DMSO at a concentration 10-3 M.The ligand and their copper complexes were screened for antimicrobial activities by the agar well diffusion technique using DMSO as solvent. The complexes were checked for their biological activity by using, Escherichia coli, and Bacillus subtilis bacteria.

Microwave Assisted Synthesis of some new Chromone and their Antibacterial Activity

“…Some of the biological activities attributed to chromones derivatives include, neuroprotective, HIV-inhibitory, antimicrobial, antibacterial, antitumor, antifungal, antialergic, antiviral, anti-inflammatory, anticancer activities. 3 Many chromone derivatives are also photoactive and can be used easily in various photo induced reactions affording diverse heterocyclic compounds. 4 These derivatives also serve as intermediates to many products of fine chemical industries such as pharmaceuticals, agrochemicals and dyestuffs.…”