2020
DOI: 10.1002/aoc.6111
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Synthesis, characterization, and density functional theory studies of hydrazone–oxime ligand derived from 2,4,6‐trichlorophenyl hydrazine and its metal complexes searching for new antimicrobial drugs

Abstract: Novel 13 mononuclear complexes derived from 3-(2-(2,4,6-trichlorophenyl) hydrazono) butan-2-one oxime with various molar ratio, geometry and different mode of interaction were prepared using transition metal Cd 2+ , Zn 2+ , Cu 2+ , Ni 2+ , Co 2+ , Fe 3+ , Mn 2+ , and VO 2+. The structure of these compounds was investigated physically, analytically, and spectrophotometrically. The ligation sites of the free 3-(2-(2,4,6-trichlorophenyl) hydrazono) butan-2-one oxime were designated via molecular modeling calculat… Show more

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Cited by 21 publications
(28 citation statements)
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References 86 publications
(196 reference statements)
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“…[47] The existence of these bands simultaneously in a ratio of 1:13 (anti: syn) reinforces the predominance of the syn-configuration over the anti-configuration of the ligand. [48] The chemical shift values attributable to the (N OH) protons of the oxime ligand are in good agreement with other previously reported oxime protons. [49][50][51][52][53] The disappearance of these signals upon the addition of D 2 O is evidence that they are assignable to OH protons.…”
Section: Nmr Spectral Studiessupporting
confidence: 91%
“…[47] The existence of these bands simultaneously in a ratio of 1:13 (anti: syn) reinforces the predominance of the syn-configuration over the anti-configuration of the ligand. [48] The chemical shift values attributable to the (N OH) protons of the oxime ligand are in good agreement with other previously reported oxime protons. [49][50][51][52][53] The disappearance of these signals upon the addition of D 2 O is evidence that they are assignable to OH protons.…”
Section: Nmr Spectral Studiessupporting
confidence: 91%
“…TLC was employedto track the progress of the reaction (hexane: ethyl acetate 70 : 30). As soon as the reaction was complete, the reaction mixture was poured onto crushed ice, whereby the solid product was filtered and dried [52] …”
Section: Methodsmentioning
confidence: 99%
“…The element analysis was performed using the Heraeus-CHN rapid-analyser. [52] A mixture of phenylhydrazine hydrochloride (2)(5 g, 0.034 mol) and 3-(hydroxyimino)butan-2-one (3) (4.2 g, 0.041 mol) in ethanol (25 ml) was refluxed for 3 hours. TLC was employedto track the progress of the reaction (hexane: ethyl acetate 70 : 30).…”
Section: Experimental Materials and Methodsmentioning
confidence: 99%
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“…[36] As a result of the exciting bioeffect of hydrazonic chelators and in continuance of our earlier researches, on the designing of bioeffective metal complexes. [37][38][39][40][41][42][43][44] This research is dedicated to preparing of new bis-hydrazone incorporating isatin moiety and its homometallic complexes with Fe 3+ , Co 2+ , Cu 2+ , and UO 2 2+ salts. The structure of synthetic compounds was studied via analytical, spectral tools as nuclear magnetic resonance (NMR), infrared (IR), mass spectrum (MS), electronic absorption spectrum (EAS), density functional theory (DFT) calculations, elemental and thermogravimetric (TG) measurements as well as the molar conductance and magnetic moment measurements for complexes was done.…”
Section: Introductionmentioning
confidence: 99%