Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions

Raju, Rajesh; Bandyopadhyay, Sulalit; Sharma, Anuvansh; González, Susana Villa; Carlsen, Per H. J.; Gautun, Odd R.; Glomm, Wilhelm R.

doi:10.3390/polym10030309

Cited by 16 publications

(9 citation statements)

References 58 publications

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“…Their synthesis, − structure, − swelling characteristics, , as well as their interaction with metal ions, small organic molecules, surfactants, , biomolecules, − and nanofibers have been investigated in detail. This wide interest is not surprising in the light of the large number of suggested applications, including drug delivery, − emulsion stabilization, − sensing, − cell encapsulation, lubrication, microgel-supported catalysis , as well as their application in the fundamental studies of, e.g., flow behavior , or glass formation, , and as a building block in macroscopic hierarchical structures. , …”

Section: Introductionmentioning

confidence: 99%

Temperature-Dependent Nanomechanical Properties of Adsorbed Poly-NIPAm Microgel Particles Immersed in Water

Varga

Kardos

et al. 2021

Langmuir

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The temperature dependence of nanomechanical properties of adsorbed poly-NIPAm microgel particles prepared by a semibatch polymerization process was investigated in an aqueous environment via indentation-based atomic force microscopy (AFM) methods. Poly-NIPAm microgel particles prepared by the classical batch process were also characterized for comparison. The local mechanical properties were measured between 26 and 35 °C, i.e., in the temperature range of the volume transition. Two different AFM tips with different shapes and end radii were utilized. The nanomechanical properties measured by the two kinds of tips showed a similar temperature dependence of the nanomechanical properties, but the actual values were found to depend on the size of the tip. The results suggest that the semibatch synthesis process results in the formation of more homogeneous microgel particles than the classical batch method. The methodological approach reported in this work is generally applicable to soft surface characterization in situ.

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Section: Introductionmentioning

confidence: 99%

Temperature-Dependent Nanomechanical Properties of Adsorbed Poly-NIPAm Microgel Particles Immersed in Water

Varga

Kardos

et al. 2021

Langmuir

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“…Chitosan/NiPAAM, poly(N-isopropylacrylamide-co-dimethyl-γ-butyrolactone acrylate-co-acrylic acid) (poly(NDBA)), and poly(N-isopropylacrylamide-co-sodium acrylate) (PNiPAAm-co-PNaAc) are some common NiPAAM based copolymers [ 166 ]. Raju et al used a bilayer hydrogel, both layers consisting of NiPAAM-based copolymers, and reported good encapsulation efficiency with L-DOPA [ 167 ]. Dosmar et al reported similarly good encapsulation (>84%) with vancomycin and demonstrated the biocompatibility of PEG-NiPAAM hydrogels [ 145 ].…”

Section: Materials Interactionsmentioning

confidence: 99%

Targeting Ocular Drug Delivery: An Examination of Local Anatomy and Current Approaches

et al. 2022

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Ocular drug delivery remains the focus of much modern research. Primary routes of administration include the surface, the intravitreal space, the subretinal space, and the subconjunctival space, each with its own series of unique challenges, limitations, and advantages. Each of these approaches requires careful consideration of the local anatomy, physical barriers, and key cells as well as the interface between the anatomy and the drug or drug system being delivered. While least invasive, the topical route poses a challenge with the many physical barriers that prevent drug penetration into the eye; while injection into the intravitreal, subretinal, and subconjunctival spaces are direct and targeted but limited due to the many internal clearance mechanisms and potential for damage to the eye. Polymeric-based, sustained-release drug delivery systems have been identified as a potential solution to many of these challenges; however, the design and successful implementation of a sustained-release system that is well-tolerated, bioactive, biocompatible, and degradable remains, in many cases, only in the early stages. The drugs and biomaterials in question also require special attention as small chemical changes could result in vastly different outcomes. This paper explores the anatomy and key cells of these four primary drug delivery routes as well as the interface between drug and drug delivery systems and the anatomy, reviewing the recent developments and current state of research in each area. Finally, this paper also examines the frequently used drugs and biomaterials found in ocular drug delivery and summarizes the primary interactions observed.

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“…Dual stimuli‐responsive nanogels generally involve a combination of redox‐responsive cross‐linkers and pH‐responsive polymeric matrix as important nanogel constituents. Some of the important examples of pH‐responsive polymers are polyacrylamide (PAAm), poly(acrylic acid) (PAA), PMAA, poly(2‐diethylaminoethyl methacrylate) (PDEAEMA), polyethyleneimine, poly( l ‐lysine), poly(2‐vinyl pyridine) (P2VP), poly( N ‐vinylamine) (PVAm), poly(4‐vinyl pyridine) (P4VP), and chitosan . The pH‐ and redox‐responsive nanogels hold excellent potential and play a diverse role for targeted intracellular release of drugs due to their multidimensional role in response to variation in GSH concentration and pH inside the cellular compartment.…”

Section: Dual and Triple Stimuli‐responsive Nanogelsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions

Cited by 16 publications

References 58 publications

Temperature-Dependent Nanomechanical Properties of Adsorbed Poly-NIPAm Microgel Particles Immersed in Water

Temperature-Dependent Nanomechanical Properties of Adsorbed Poly-NIPAm Microgel Particles Immersed in Water

Targeting Ocular Drug Delivery: An Examination of Local Anatomy and Current Approaches

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

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