Synthesis, Characterization and Effect of a Solvent Mixture on the CMC of a Thio‐Based Novel Cationic Surfactant Using a UV–Visible Spectroscopic Technique

Ullah, Imdad; Ahmad, Khurshid; Shah, Afzal; Badshah, Amin; Rana, Usman Ali; Shakir, Imran; Rehman, Zia ur; Khan, Shahan Zeb

doi:10.1007/s11743-013-1554-1

Cited by 11 publications

(9 citation statements)

References 23 publications

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“…CMC was determined by plotting UV-vis absorbance versus surfactant concentration [18]. DAP-T was read in a concentration range of 0.01-0.1 mM, yielding maximum absorbance at 323 nm as shown in Fig.…”

Section: Determination Of Cmcmentioning

confidence: 99%

Synthesis of Sulfur‐Based Biocompatible Nonionic Surfactants and Their Nano‐Vesicle Drug Delivery

Ali

Shah

Imran

et al. 2017

J Surfact & Detergents

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Nonionic surfactants are capable of forming nano‐range vesicles upon self‐assembling in an aqueous medium. These vesicles are highly stable, low in toxicity, and cost‐effective. Owing to their ability to solubilize both hydrophilic and hydrophobic substances, they are of great interest for drug solubilization and delivery. This study describes the synthesis and characterization of two new nonionic surfactants and their screening for biocompatibility and drug loading potentials in nano‐scale niosomal vesicles. They were characterized through mass spectroscopy, 1HNMR, and FT‐IR. Their critical micelle concentration (CMC) was investigated using UV–vis spectrophotometry. The biocompatibility study was carried out through blood hemolysis and in vitro cytotoxicity assays. The surfactants have very low CMC values, are highly hemo‐compatible, and were nontoxic when tested against a cell culture. They were able to form nano‐range niosomal vesicles with large variation in their size. Both new surfactants were able to encapsulate increased amounts of the drug, in this case clarithromycin. The chemical nature of the drug remained intact in the niosomal vesicles. The results suggest that these nonionic surfactants could be promising drug delivery vehicles.

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Section: Determination Of Cmcmentioning

confidence: 99%

Synthesis of Sulfur‐Based Biocompatible Nonionic Surfactants and Their Nano‐Vesicle Drug Delivery

Ali

Shah

Imran

et al. 2017

J Surfact & Detergents

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“…Above certain concentration, nonionic surfactants get self‐aggregated in aqueous medium and form supramolecular structures called micelles. Concentration at which surfactants form micelles is known CMC (I. Ullah et al, ). It is one of the important characteristics of nonionic surfactants and its determination predicts various properties such as their self‐assembling and capabilities of detergency and solubilization.…”

Section: Resultsmentioning

confidence: 99%

“…Concentration at which surfactants form micelles is known CMC (I. Ullah et al, 2014). It is one of the important characteristics of nonionic surfactants and its determination predicts various properties such as their self-assembling and capabilities of detergency and solubilization.…”

Section: Cmc Determinationmentioning

confidence: 99%

Synthesis of Biocompatible Double‐Tailed Nonionic Surfactants and Their Investigation for Niosomal Drug‐Loading Applications

Ali

Shah

Nadeem

et al. 2019

J Surfact & Detergents

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Nonionic surfactants are capable of self‐assembling and thus are of vital importance for designing various drug‐delivery systems. This study reports the synthesis, characterization, biocompatibility, and drug‐loading potential of sulfanilamide‐based novel nonionic surfactants. These surfactants were synthesized in a single‐step reaction and characterized using nuclear magnetic resonance (NMR), electron impact mass spectroscopy, and fourier‐transforminfrared spectroscopy (FTIR). Critical micelle concentration (CMC) of the synthesized nonionic surfactants was determined using a ultraviolet–visible (UV) spectrophotometer. The surfactant potential for niosomal vesicles was explored using simvastatin as a model drug. The drug‐loaded vesicles were screened for shape, size, size distribution, and percent drug entrapment efficiency (EE%) using atomic force microscopy (AFM), zeta potential, and UV–visible spectrophotometry. Biocompatibility of the synthesized surfactants was investigated through blood hemolysis and cell toxicity assays. Synthesized nonionic surfactants revealed lower CMC values of 0.045–0.095 mM and entrapped an improved amount of drug upon self‐simplifying in niosomal vesicles. Findings of the study confirm these nonionic surfactants as hemocompatible and nontoxic candidates for vesicular drug‐delivery applications.

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“…UV-visible spectrophotometry was performed with the VWR brand double beam spectrophotometer; model UV-6300PC with UV-Visible scanning. This technique was used to determine the critical micellar concentration (CMC) value roughly, whereas a micellar solution acts as a colloidal suspension relative to the wavelength of light [ 20 ]. This method is based on the change in absorption behavior after aggregation [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of a Bioconjugate Based on Oleic Acid and L-Cysteine

et al. 2021

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One of the main challenges facing materials science today is the synthesis of new biodegradable and biocompatible materials capable of improving existing ones. This work focused on the synthesis of new biomaterials from the bioconjugation of oleic acid with L-cysteine using carbodiimide. The resulting reaction leads to amide bonds between the carboxylic acid of oleic acid and the primary amine of L-cysteine. The formation of the bioconjugate was corroborated by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and nuclear magnetic resonance (NMR). In these techniques, the development of new materials with marked differences with the precursors was confirmed. Furthermore, NMR has elucidated a surfactant structure, with a hydrophilic part and a hydrophobic section. Ultraviolet-visible spectroscopy (UV-Vis) was used to determine the critical micellar concentration (CMC) of the bioconjugate. Subsequently, light diffraction (DLS) was used to analyze the size of the resulting self-assembled structures. Finally, transmission electron microscopy (TEM) was obtained, where the shape and size of the self-assembled structures were appreciated.

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Synthesis, Characterization and Effect of a Solvent Mixture on the CMC of a Thio‐Based Novel Cationic Surfactant Using a UV–Visible Spectroscopic Technique

Cited by 11 publications

References 23 publications

Synthesis of Sulfur‐Based Biocompatible Nonionic Surfactants and Their Nano‐Vesicle Drug Delivery

Synthesis of Sulfur‐Based Biocompatible Nonionic Surfactants and Their Nano‐Vesicle Drug Delivery

Synthesis of Biocompatible Double‐Tailed Nonionic Surfactants and Their Investigation for Niosomal Drug‐Loading Applications

Synthesis and Characterization of a Bioconjugate Based on Oleic Acid and L-Cysteine

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