Synthesis, Characterization and Evaluate the Biological Activity of Novel Heterocyclic Derivatives from Azomethine Compounds

Abstract

This research includes synthesis of new seventh-membered heterocyclic derivatives as 1,3-oxazepine-dione derived from azomethine compounds. Azomethine compounds R1-R4 were synthesized by the reaction of aromatic aldehydes with primary aromatic amines. The novel of 1,3-oxazepine-dione derivatives R5-R9 were obtained from the treatment of azomethine compounds with anhydrides. The synthesized compounds were checked by TLC technique, spectral methods (FT-IR, H1-NMR) and measurements of some its physical properties. The biological activity of the heterocyclic derivatives was investigated against bacteria and fungi in vitro.

Study Some New Metallic Coordination Complexes and their Antibacterial Activity Against Methicillin- Resistant Staphylococcus Aureus

“…The ratio of 2 ligands was then dissolved in a mixture of (ethanol and methanol) and 1 ml of ruthenium chloride or gold chloride dissolved in ethanol (11,12) , then rose for 4h, filtered the solution, and washed with water and ethanol.…”

“…(3,4) In the industrial area, they are used as anti-corrosion materials, polymerization catalysts, ink dyeing, and printing (5.6). The Schiff Base (imin compounds) consist of a condensate reaction of primary amines with aldehydes first prepared by the German scientist Schiff in 1864 and is distinguished by its containment of the effective isomethane group (C = N) and its formula (7) .…”

Fabrication of acid‐labile poly(2‐hydroxyethyl methacrylate) nanoparticles using aldazine‐based crosslinker as pH‐sensitive drug nanocarriers

“…Aldazines are the compounds obtained by condensation reaction of two equivalents of an aromatic aldehyde with one equivalent of hydrazine and because of containing a CN group, they have been popularly called Schiff bases. These synthones are the functional class of azomethine compound that received increasing attention in recent years for their antitumor, 24 antibacterial, 25,26 anti‐inflammatory, 27 and antifungal 28 properties. These compounds are photochromic and exhibit both photochemical and thermal isomerization for the CN bond and also tend to rotate around the NN bond to form thermodynamically stable s‐trans and gauche forms 29 .…”