Synthesis, characterization, and evaluation of chloroaluminium phthalocyanine incorporated in poly(ε-caprolactone) nanoparticles for photodynamic therapy

Pinto, Bruna C S; Ambrósio, Jéssica Aparecida Ribeiro; Marmo, Vitor Luca Moura; Pinto, Juliana Guerra; Raniero, Leandro; Ferreira‐Strixino, Juliana; Simioni, Andreza Ribeiro; Beltrame, Milton

doi:10.1016/j.pdpdt.2022.102850

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…The system is stabilized against agglomeration by the magnitude of zeta potential, which reflects the strength of electrostatic repulsion between particles with identical charges in dispersion [ 71 ]. All the prepared LOR-loaded bilosomes obtained negative zeta potential values which ranged from −17.8 ± 1.2 to −44.3 ± 1.08 mV (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Ibrahiem,

Shamma,

Salama

et al. 2023

Drug Deliv. and Transl. Res.

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Osteoarthritis is a bone and joint condition characterized pathologically by articular cartilage degenerative damage and can develop into a devastating and permanently disabling disorder. This investigation aimed to formulate the anti-inflammatory drug lornoxicam (LOR) into bile salt–enriched vesicles loaded in an in situ forming hydrogel as a potential local treatment of osteoarthritis. This was achieved by formulating LOR-loaded bilosomes that are also loaded with superparamagnetic iron oxide nanoparticles (SPIONs) for intra-muscular (IM) administration to improve joint targeting and localization by applying an external magnet to the joint. A 31.22 full factorial design was employed to develop the bilosomal dispersions and the optimized formula including SPION (LSB) was loaded into a thermosensitive hydrogel. Moreover, in vivo evaluation revealed that the IM administration of LSB combined with the application of an external magnet to the joint reversed carrageen-induced suppression in motor activity and osteoprotegerin by significantly reducing the elevations in mitogen-activated protein kinases, extracellular signal-regulated kinase, and receptor activator of nuclear factor kappa beta/osteoprotegerin expressions. In addition, the histopathological evaluation of knee joint tissues showed a remarkable improvement in the injured joint tissues. The results proved that the developed LSB could be a promising IM drug delivery system for osteoarthritis management. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Ibrahiem,

Shamma,

Salama

et al. 2023

Drug Deliv. and Transl. Res.

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“…Researchers have also focused on the encapsulation of Pcs in drug delivery systems, such as micelles [ 233 ], liposomes [ 234 ], nanocapsules [ 235 ], nanoemulsions [ 236 ], and, interestingly, in “nanodiamonds” [ 237 , 238 ].…”

Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Lima

Reis

2023

Molecules

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Photodynamic therapy, an alternative that has gained weight and popularity compared to current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic strategy that generally results from the simultaneous action of three factors: a molecule with high sensitivity to light, the photosensitizer, molecular oxygen in the triplet state, and light energy. There is much to be said about each of these three elements; however, the efficacy of the photosensitizer is the most determining factor for the success of this therapeutic modality. Porphyrins, chlorins, phthalocyanines, boron-dipyrromethenes, and cyanines are some of the N-heterocycle-bearing dyes’ classes with high biological promise. In this review, a concise approach is taken to these and other families of potential photosensitizers and the molecular modifications that have recently appeared in the literature within the scope of their photodynamic application, as well as how these compounds and their formulations may eventually overcome the deficiencies of the molecules currently clinically used and revolutionize the therapies to eradicate or delay the growth of tumor cells.

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“…Over the past 20 years, a renewed interest in these complexes has been triggered by the possibility of associating them with nanoparticles [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…This association is most often made at the periphery of the phthalocyanine macrocycle through -SH, -NH 2 , -COOH groups, etc. The resulting hybrid species often aggregate which limits their field of application in solution [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Study of the Physicochemical Properties of a Hybrid Species: Iron Phthalocyanine–Silver Nanoparticles

et al. 2022

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This article reports a strategy to synthesize a hybrid species made of iron phthalocyanine (FePc) grafted to the surface of silver nanoparticles. The affinity between sulfur and silver on the one hand, and the aptitude of the FePc complex to bind pyridine axially on the other, allowed us to use thiopyridine as a linker between the two entities. The hybrid species, isolated in the solid form for the first time, has been characterized by optical and vibrational spectroscopy, and by transmission electron microscopy. These studies confirm the good aptitude of the linker to connect the FePc to the silver nanoparticles.

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Synthesis, characterization, and evaluation of chloroaluminium phthalocyanine incorporated in poly(ε-caprolactone) nanoparticles for photodynamic therapy

Cited by 6 publications

References 41 publications

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Synthesis and Study of the Physicochemical Properties of a Hybrid Species: Iron Phthalocyanine–Silver Nanoparticles

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