Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Abstract

Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R 2 NCS 2 ) were prepared by the reaction of these ligands with (CH 3 ) 2 S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP) 2 ]Cl (2), and [Au 2 (R 2 NCS 2 ) 2 ] n (R 2 = dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by ele-* Dr. A. A. Isab

Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

“…128 -7). 129 The chloro(triphenylphosphine)gold(I) is a forefront reagent in gold chemistry since the majority of the gold(I) complexes are derived by the substitution of chlorine atom. In 2018, Chrysouli et al studied the antiproliferative activity of the gold complex chloro(triphenylphosphine)gold(I) 172 on MCF-7.…”

“…The cytotoxic IC 50 values of complex 171 against these three cell lines were 53.97 ± 0.94 μM (A549), 51.2 ± 0.83 μM (HCT15), and 38.34 ± 0.22 μM (MCF-7). 129 The chloro(triphenylphosphine)gold( i ) is a forefront reagent in gold chemistry since the majority of the gold( i ) complexes are derived by the substitution of chlorine atom. In 2018, Chrysouli et al studied the antiproliferative activity of the gold complex chloro(triphenylphosphine)gold( i ) 172 on MCF-7.…”

Novel dinuclear gold(i) complexes containing bis(diphenylphosphano)alkanes and (biphenyl-2-yl)(di-tert-butyl)phosphane: synthesis, structural characterization and anticancer activity

“…Considering these studies and in continuation of our focus on the structural and antitumor properties of the gold( i ) complexes of phosphanes, 13–16,42–45 we report here the synthesis of a novel series of gold( i ) complexes ( 1–4 ) containing both mono-phosphane {(biphenyl-2-yl)di- tert -butylphosphane, Bdbp} and diphosphanes {1,2-bis(diphenylphosphano)ethane, Dppe; 1,3-bis(diphenylphosphano)propane, Dppp; 1,4-bis(diphenylphosphano)butane, Dppb and bis[2-(diphenylphosphano)methyl]amine, Dpma} ligands. The complexes were characterized by FTIR, NMR ( 1 H and 13 C) spectroscopic methods, and their structures were determined by single crystal X-ray diffraction analysis.…”

Cancer cell-selective modulation of mitochondrial respiration and metabolism by potent organogold(iii) dithiocarbamates

“…27,[33][34][35][36] Among such complexes are Au(III)-2-pyridylmethanol, 37 Au(III)dichloro(N-ethylsalicylaldiminate), 38 Au(III)-phosphine, [39][40][41] cyclometalated Au(III), 27,34,[42][43][44][45][46] and Au(III)dithiocarbamates. 45,[47][48][49][50][51][52] Whereas different classes of Au(III)dithiocarbamate display promising anticancer activity in vitro and in vivo the mechanism of action is not well elucidated. 45,53 Herein, we report the synthesis of Au(III) dithiocarbamates that incorporate aryl-pyridine cyclometallation [C^N] ligands to improve complex stability and different aryl/alkyl dithiocarbamate ligands for structure activity relationship (SAR).…”