1994
DOI: 10.1155/mbd.1995.37
|View full text |Cite
|
Sign up to set email alerts
|

Synthesis, Characterization and In vitro Antitumour Activityof Novel Organotin Derivatives of 1,2‐ and1,7‐Dicarba‐Closo‐dodecaboranes

Abstract: Several organotin derivatives of 1,2-and 1,7-dicarba-closo-dodecaboranes were synthesized and characterized by lgsn M6ssbauer, 1H, 13C and 19Sn NMR spectroscopy.Their antitumour activities in vitro against cancerous cell lines of human origin are reported.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
16
0

Year Published

1998
1998
2009
2009

Publication Types

Select...
5
2

Relationship

3
4

Authors

Journals

citations
Cited by 27 publications
(16 citation statements)
references
References 1 publication
0
16
0
Order By: Relevance
“…9) were also screened. 102,103 Boron, furthermore, is an element that can be useful for neutron capture cancer therapy, for compounds accumulating in localized tumours. In compounds 8, 9, and 10 the tin atom is linked directly to one of the boron atoms of the carbonane moiety.…”
Section: Antitumour Screening Of Boron-containing Organotin Carboxylatesmentioning
confidence: 99%
“…9) were also screened. 102,103 Boron, furthermore, is an element that can be useful for neutron capture cancer therapy, for compounds accumulating in localized tumours. In compounds 8, 9, and 10 the tin atom is linked directly to one of the boron atoms of the carbonane moiety.…”
Section: Antitumour Screening Of Boron-containing Organotin Carboxylatesmentioning
confidence: 99%
“…The diorganotins represent the largest group of tin compounds to have been extensively examined for cytotoxicity in vitro; however, they are, in general, less toxic than platinum complexes. 11,12 Literature reveals that hydrolysable organotin(IV) carboxylates significantly retard tumour growth and the non-hydrolysable forms show no activity. 13 It has also been proposed that their mode of action might involve the initial transportation of the complex [R 2 SnCl 2 · 2L] into the tumourigenic cells followed by the reaction of [R 2 SnCl 2 ] or one of its hydrolysed products.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the coordination of SnPh 3 Mössbauer spectra were obtained as described previously. 16 Boron, tin and sodium elemental analyses were performed by the express-gravimetry method of Pregl-Korshun.…”
Section: 8mentioning
confidence: 99%
“…Some of them contain a carborane cage linked to the tin atom via a B-Sn σ -bond. 3 Organotin carboranecarboxylates in which the carborane cage is linked to the carboxylic moiety via a carbon 4,5 or boron 6 atom have been studied. All carborane-based organotin compounds previously tested have revealed in vitro antitumour activities that are less than those of the clinically used methotrexate and doxorubicin, but greater than those of 5-fluorouracil, cis-platin and carboplatin.…”
Section: Introductionmentioning
confidence: 99%