Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3‐Diphenyl‐1,3‐propanedione

Abstract

Schiff bases are organic compounds formed by the reaction of the primary aminewith carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentateligands capable of forming very stable complexes with transitional metals. They areused as catalysts in oxygenation, hydrolysis, electro-reduction and decompositionreactions. Many Shiff bases show significant anti-tumor, antimicrobial and antifungalactivity, which are the subject of research by many scientists in the world.In this paper Schiff base from benzidine and 1,3-diphenyl-1,3-propanedione wassynthesized. To characterize the product, FTIR spectroscopy and stereo-microscopywere used. In order to determine biological activity, antibacterial, antifungal andantioxidant activity of the product was tested.The results showed that the interaction of benzidine and 1,3-diphenylpropanedioneresults in a Schiff base showing antibacterial, antifungal and antioxidant activity.

Metal complexes as potential agents for neutralizing free radicals: a review of in vitro studies

“…Studies conducted in the past two years on complexes of selected d-block metals and Schiff bases derived from ninhydrin and amino acids have shown significant reduction potential and a high degree of neutralization of DPPH radicals in in vitro studies [18][19][20][21]. Figure 2 shows the general structure of metal complexes with Schiff bases derived from selected amino acids and ninhydrins, where R is the amino acid residue (phenylalanine, glycine, tryptophan, methionine, histidine, cysteine) and M is the selected metals (copper, cobalt, iron, nickel, silver).…”

Chemistry in biosystem—A contemporary review of Schiff bases and their metal complexes as antioxidants and anti-fungal agents

“…Regarding AO activity, in ligand complex pairs (L1-1 and L2-2), highest inhibitory action was seen in complexes 1 and 2 (Figure 12). Schiff base was obtained from benzidine with 1,3-diphenyl-1,3-propanedione and its AO and AF activities were studied by Horozić et al [43] (Figure 13). The AO activity was studied in vitro using DPPH method.…”

In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases

“…Ongoing research is focused on understanding the biology of K. pneumonia and developing new treatments and preventative measures to combat its spread. 6 Pseudomonas aeruginosa, gram-negative bacterium that is widespread in clay and moisture is an adaptable disease-causing bacterium that can trigger a range of infections, notably in hospitalized patients, including pneumonia, sepsis, pyelonephritis, and surgical wound infestation. P. aeruginosa is known to develop resistance to multiple antibiotics, making treatment challenging.…”