Synthesis, characterization and in vivo drug delivery study of a biodegradable nano-structured molecularly imprinted polymer based on cross-linker of fructose

Asadi, Ehsan; Abdouss, Majid; Leblanc, Roger M.; Ezzati, Noushin; Wilson, James N.; Kordestani, Davood

doi:10.1016/j.polymer.2016.05.031

Cited by 59 publications

(35 citation statements)

References 51 publications

(60 reference statements)

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“…The sustained and stimuli-responsive release of bioactive compounds has been explored in the development of MIPs as delivery systems for various administration routes (e.g., ocular, dermal, oral, or intravenous) of other therapeutics as well [12,13]. Examples include but are not limited to antipyretics [112], anti-Alzheimer drugs [113] and antipsychotics [114] smoking cessation agents [115], and β-adrenergic antagonists [116].…”

Section: Other Therapeutic Applicationsmentioning

confidence: 99%

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.Polymers 2019, 11, 2085 2 of 33 normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.Polymers 2019, 11, x FOR PEER REVIEW 2 of 34 of both normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.

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Section: Other Therapeutic Applicationsmentioning

confidence: 99%

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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“…One of the main obstacles toward nanocarriers’ efficacy in drug delivery could be the lack of knowledge about the precise bio-distribution, location and subsequent therapeutic effects, as most studies have not examined the targeting efficiency of NPs real time in vivo [ 28 ]. With this regard, among the active targeted MIP-based systems [ 53 , 54 , 63 , 64 , 65 , 66 ], MMIPs are appealing [ 53 , 64 , 65 ] because of the ease of active remote guidance to the site of interest in the body by using an external magnetic field. Regarding tumor chemotherapy, this feature largely enhances the drug concentration in the tumor tissues by much lower costs and potentially improves its therapeutic efficacy while narrowing the adverse toxicity to healthy cells through tumor local accumulation [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

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“…21 Some groups have reported magnetic imprinted materials dedicated to drug delivery. For example, Asadi 22 reported a new biodegradable cross-linker agent based on fructose for the fabrication of a brain-targeting MIP, where the magnetic structure of the prepared MIP facilitates the aggregation of carriers near the target tissue under a magnetic eld. Hemmati 23 prepared a highly selective magnetic molecularly imprinted polymer (MMIP) as a drug delivery device synthesized by a sol-gel process composed of Tragacanth Gum (TG) crosslinker, Fe 3 O 4 /SiO 2 nanoparticles, and an N-vinyl imidazole (VI) functional monomer in the presence of the template, Quercetin (QC).…”

Section: Introductionmentioning

confidence: 99%

Drug-loaded dual targeting graphene oxide-based molecularly imprinted composite and recognition of carcino-embryonic antigen

Han

Yuan

et al. 2020

RSC Adv.

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Synthesis, characterization and in vivo drug delivery study of a biodegradable nano-structured molecularly imprinted polymer based on cross-linker of fructose

Cited by 59 publications

References 51 publications

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Drug-loaded dual targeting graphene oxide-based molecularly imprinted composite and recognition of carcino-embryonic antigen

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