Synthesis, characterization and interaction with DNA of mononuclear metal complexes with oxolinic acid

Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure–activity relationship

“…2). The complexes also exhibit an absorption band, as a shoulder, at 430 nm (e = 120-140 M À1 cm À1 ) which can be assigned to the ligand-to-metal charge-transfer transition for the sparfloxacinato ligand, as it has been observed in a series of quinolones-metal complexes [27][28][29][30][31][32][33][34][35]. Finally, the UV spectra of the complexes are practically identical with those of the quinolone sparfloxacin, while differences due to the N-donor ligands (bipy, phen, and bipyam) are not easily distinguished [27][28][29][30].…”

“…In our previous work, we have studied the structures, the spectroscopic and the biological properties of diverse transition metal complexes with various quinolone antibacterial drugs [25,[27][28][29][30][31][32][33][34][35][36][37]. On this basis, we present the interaction of Cu(II) with the third-generation quinolone sparfloxacin in the presence of the N-donor heterocyclic ligands bipy, phen or bipyam (Scheme 1) in an attempt to examine the mode of coordination and the biological properties of the resultant complexes.…”

Zinc complexes of the antibacterial drug oxolinic acid: Structure and DNA-binding properties

“…In the UV region, the intense absorption bands observed in the spectra of Hoxo and the complexes are attributed to the intraligand p ? p * transition of the coordinated groups of oxolinato ligands [28,32] and the N-donor ligands for 2 and 3. Any interaction between each compound and CT DNA could perturb the intra-ligand centred spectral transitions of the compound [70].…”

“…The study of the biological properties of quinolones has been focused on the interaction with DNA [19], antibacterial activity tests on diverse microorganisms [20,21], cytotoxicity [21,22] and potential antitumor activity [23]. The study of the biological properties of quinolone metal complexes comprises mainly their antibacterial activity against diverse microorganisms [24][25][26], the interaction with DNA [27][28][29][30][31][32][33][34][35][36] and, in some cases, the potential antitumor activity [35,36].…”

Nickel–quinolones interaction. Part 1 – Nickel(II) complexes with the antibacterial drug sparfloxacin: Structure and biological properties

“…The study of the biological properties of quinolones or their metal complexes has been focused on the interaction with DNA [17][18][19][20][21], antibacterial activity tests on diverse microorganisms [22][23][24], cytotoxicity [24,25] and potential antitumor activity [26][27][28].…”