Synthesis, Characterization and Pharmacological Screening of Some Substituted 1,2,3- & 1,2,4-Triazoles

Abstract

The triazole nucleus is an important part of the therapeutically interesting drug candidate as antimicrobial, analgesic, anticancer, anticonvulsant and anti-inflammatory agents. Therefore, a number of 1,2,3-& 1,2,4-triazole derivatives were synthesized. The structures of these compounds were characterized by means of FT-IR, 1 H-NMR, and elemental analysis. All the compounds were evaluated for antimicrobial activity, using Kirby-Bauer disk diffusion method and anti-inflammatory activity, using carrageenan-induced acute paw oedema method. Some of the compounds exhibited encouraging antimicrobial and anti-inflammatory results when compared with standard drugs.

Removal Bismarck Brown G dye from Aqueous Solution Over a Composite of Triazole-Polyvinyl Chloride Polymer and Zinc Oxide

“…The band around 2920 cm -1 can be assigned to aliphatic (C-H). The band around 3070 cm -1 is related to C-H aromatic and that around 2936 cm -1 C-H aliphatic 20 . The band around 1569 cm -1 is assigned to C=C, and that around 1648 cm -1 is related to C=N.…”

“…The band around 737 -1 C-H bending of ortho substituted benzene ring. The band around 3448 cm -1 is assigned to OH stretching modes 20 . The band around 3321 cm -1 is attributed to NH stretching modes.…”

Thermal stabilization of energetic materials by the aromatic nitrogen-rich 4,4′,5,5′-tetraamino-3,3′-bi-1,2,4-triazolium cation

“…A high density is vital for a good performance of the energetic material, since the detonation pressure is proportional to its squared density. [2] Next to equal or even enhanced physical properties, the demand for "green", nitrogen-rich energetic materials steadily 35 rises. To reduce the pollution of the environment through commonly used toxic and carcinogenic explosives, like RDX or lead azide, explosives releasing mostly dinitrogen after decomposition gain more and more importance.…”

Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications

“…35 The conjugated NPs were also characterized for their mean hydrodynamic diameter and surface charge which were measured at 137 ± 29.5 nm and +25 ± 0.2 mV, respectively. The biocompatibility of the USPIO NPs functionalized with the PEG oligomers 6 and 7 was assessed using the hemolytic assays.…”