Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

Al-Tabakha, Moawia M.; Khan, Shujaat Ali; Ashames, Akram; Ullah, Hamid; Ullah, Kaleem; Murtaza, Ghulam; Hassan, Nageeb

doi:10.3390/ph14030234

Cited by 48 publications

(35 citation statements)

References 44 publications

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“…Ganciclovir is a derivative of acyclovir and has promising efficacy against cytomegalovirus infection. [ 1,7–11 ] The goal of this work is to develop a potent drug that can be used to defeat the deadly COVID‐19. Density functional theory (DFT) analysis has proven to be an effective tool that is commonly used by researchers to establish the stability of compounds.…”

Section: Introductionmentioning

confidence: 99%

An insight for the interaction of drugs (acyclovir/ganciclovir) with various ionic liquids: DFT calculations and molecular docking

Kumar

Kumari

Singh

et al. 2021

J of Physical Organic Chem

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Since December 2019, the humanity is in trouble due to the huge infection of SARS‐CoV‐2 and caused COVID‐19, named by WHO. Therefore, researchers and health care organizations are using the repurposing drugs against the infection by this new coronavirus. Acyclovir and ganciclovir are the drugs used in the cure of infection due to herpes virus so the impact of these drugs along with the designed ionic liquids individually as well as in combination against the Mpro of nCoV was investigated using molecular docking. The drugs {acyclovir (1) and ganciclovir (2)}, ionic liquids (A, B, and C), and their combinations (1‐A, 1‐B, 1‐C, 2‐A, 2‐B, and 2‐C) were studied using density functional theory (DFT) calculations via determining the different energies. These values are important to understand the formation of 1‐A, 1‐B, 1‐C, 2‐A, 2‐B, and 2‐C and are found to negative. Complexes formed by acyclovir with ILs (B and C) are more favorable due to less value of change in free energy. Further, 1 interacts with IL(C) and 2 interacts well with IL(A), and it is based on the calculated dipole moment of 1‐C and 2‐A, as 17.4 and 27.6, respectively. Therefore, it can be considered as more polar and more water soluble. Results revealed that complex 2‐A found to more stable than 1‐A and showed the best binding energy of −149 kcal/mol against the Mpro of nCoV. It indicates that the drug, ganciclovir (2) in presence of the IL(A) binds effectively with the Mpro of nCoV instead independently.

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Section: Introductionmentioning

confidence: 99%

An insight for the interaction of drugs (acyclovir/ganciclovir) with various ionic liquids: DFT calculations and molecular docking

Kumar

Kumari

Singh

et al. 2021

J of Physical Organic Chem

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“…Sadat concluded [22] that there are different adsorption mechanisms for acyclovir on magnetite nanoparticles with different sizes. A matrix-based antiherpetic ring composed of poly(ethylene-co-vinyl acetate) was used to release acyclovir to the vaginal epithelium [25] and New strategies based on complex nanostructures for developing advanced functional materials providing sustained release acyclovir were published recently using coreshell nano ber [26] and sericin hydrogel [27].…”

Section: Hui Et Alii Observed That the Combination Of Acyclovir And Dmentioning

confidence: 99%

Pseudoboehmite as a drug delivery system for acyclovir

Peres

Sousa

Oliveira

et al. 2021

Preprint

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Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of low permeability across the gastrointestinal membrane. Based on experiments using nanoparticles of pseudoboehmite as a drug delivery system in vitro assays it was concluded that pseudoboehmite could be used for acyclovir release. We report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles. Pseudoboehmite was characterized by several techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content in the plasma of Wistar rats after 4 h administration. The toxicity of pseudoboehmite was also evaluated using the Caco-2 cell line (ATCC).

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“…Heat-stable gels can be developed at room temperature [ 8 ]. Acrylic acid (AA) is an aqueous, soluble and pH-sensitive polymer employed mostly in stimuli responsive polymeric carrier systems, especially in pH-sensitive hydrogels [ 9 ]. Due to its pH responsive nature, AA is used widely in different biomedical and pharmaceutical fields as it releases a high quantity of drug at the target site.…”

Section: Introductionmentioning

confidence: 99%

Preparation and In Vitro Evaluation of Aspartic/Alginic Acid Based Semi-Interpenetrating Network Hydrogels for Controlled Release of Ibuprofen

Suhail

Hsieh

Khan

et al. 2021

Gels

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Different combinations of polymers, aspartic acid (ASP), alginic acid (AL), and monomer acrylic acid (AA) were crosslinked in the presence of an initiator ammonium peroxodisulfate (APS) and cross-linker ethylene glycol dimethacrylate (EGDMA) to develop aspartic acid/alginic acid-co-poly(acrylic acid) (ASP/ALPAA) (semi-interpenetrating polymer network (SIPN)) hydrogels by the free radical polymerization technique for the controlled delivery of ibuprofen (IBP). Various studies such as dynamic swelling studies, drug loading, in vitro drug release and sol−gel analysis were carried out for the hydrogels. Higher swelling was observed at higher pH 7.4 as compared to lower pH 1.2, due to the presence of carboxylic groups of polymers and the monomer. Hence, pH-dependent swelling was exhibited by the developed hydrogels which led to a pH-dependent drug release and vice versa. The structural properties of the hydrogels were assessed by FTIR, PXRD, TGA, DSC, and SEM which confirmed the fabrication and stability of the developed structure. FTIR analysis revealed the reaction of both polymers with the monomer during the polymerization process and confirmed the overlapping of the monomer on the backbone of the both polymers. The disappearance of high intense crystalline peaks and the encapsulation of the drug by the hydrogel network was confirmed by PXRD. TGA and DSC showed that the developed hydrogels were thermally more stable than their basic ingredients. Similarly, the surface morphology of the hydrogels was analyzed by SEM and showed a smooth surface with few pores. Conclusively, ASP/ALPAA hydrogels have the potential to deliver IBP for a long period of time in a controlled way.

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Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

Cited by 48 publications

References 44 publications

An insight for the interaction of drugs (acyclovir/ganciclovir) with various ionic liquids: DFT calculations and molecular docking

An insight for the interaction of drugs (acyclovir/ganciclovir) with various ionic liquids: DFT calculations and molecular docking

Pseudoboehmite as a drug delivery system for acyclovir

Preparation and In Vitro Evaluation of Aspartic/Alginic Acid Based Semi-Interpenetrating Network Hydrogels for Controlled Release of Ibuprofen

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