Synthesis, Characterization and Surface Activity of New Eco‐friendly Schiff Bases Vanillin Derived Cationic Surfactants

Nonionic surfactants are capable of forming nano‐range vesicles upon self‐assembling in an aqueous medium. These vesicles are highly stable, low in toxicity, and cost‐effective. Owing to their ability to solubilize both hydrophilic and hydrophobic substances, they are of great interest for drug solubilization and delivery. This study describes the synthesis and characterization of two new nonionic surfactants and their screening for biocompatibility and drug loading potentials in nano‐scale niosomal vesicles. They were characterized through mass spectroscopy, 1HNMR, and FT‐IR. Their critical micelle concentration (CMC) was investigated using UV–vis spectrophotometry. The biocompatibility study was carried out through blood hemolysis and in vitro cytotoxicity assays. The surfactants have very low CMC values, are highly hemo‐compatible, and were nontoxic when tested against a cell culture. They were able to form nano‐range niosomal vesicles with large variation in their size. Both new surfactants were able to encapsulate increased amounts of the drug, in this case clarithromycin. The chemical nature of the drug remained intact in the niosomal vesicles. The results suggest that these nonionic surfactants could be promising drug delivery vehicles.

Section: Introductionmentioning

confidence: 99%

Synthesis of Sulfur‐Based Biocompatible Nonionic Surfactants and Their Nano‐Vesicle Drug Delivery

Ali

Shah

Imran

et al. 2017

“…Also vanillin used as pesticide, green corrosion inhibitors for corrosion of different metals [11]. Vanillin has many advantages such as low cost, non-toxicity and easy production with the annual production capability in the world being able reach up to 12,000 ton [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Surface, Thermodynamic Properties of Some Biodegradable Vanillin‐Modified Polyoxyethylene Surfactants

Sayed

Ghuiba

Abdou

et al. 2012

Four water‐soluble non‐ionic ethoxylated surfactants based on vanillin were synthesized (VE15, VE20, VE40, and VE60). The chemical structures of these surfactants were confirmed using FT‐IR and 1H‐NMR spectra. The molecular weights of the compounds were determined using viscosity measurements and gel permeation chromatography. Surface tension as a function of the concentration of the surfactant in aqueous solution was measured at 25, 40 and 55 °C. From these measurements, the critical micelle concentration (CMC), effectiveness (πcmc), efficiency (pC20), maximum surface (Γmax) excess and minimum surface area (Amin), were calculated. The surface activity measurements showed their high tendency towards adsorption and micellization and their good surface tension reduction, and low interfacial tension. The emulsion stability measurements showed the applicability of these surfactants as emulsifying agents. The thermodynamic parameters of micellization (ΔGmic, ΔHmic, ΔSmic) and adsorption (ΔGads, ΔGads, ∆Sads) showed their tendency towards adsorption at the interfaces and also micellization in the bulk of their solutions. The biodegradability of the prepared surfactants was tested in river water using die‐away method and showed their readily biodegradation in the open environment.

“…The ability of 400S, 400V, 600S and 600V towards biodegradation in river water was determined by surface tension method (Du-Noüy tensiometer, Krüss type K6) using a platinum ring [42,43] at an inhibitor concentration of 1 % by weight. Inhibitors were dissolved in river water with a concentration of 100 ppm and were incubated at 38°C.…”

Section: Biodegradability Testmentioning

confidence: 99%

Environmentally Friendly Nonionic Surfactants Derived from Jatropha Oil Fatty Acids as Inhibitors for Carbon Steel Corrosion in Acidic Medium

Negm

Badr

Zakaria

et al. 2015

Self Cite

The inhibition effect of four novel environmentally friendly inhibitors (derived from vanillin and a fatty acid mixture obtained from the hydrolysis of Jatropha oil) on carbon steel corrosion in 0.5 M H 2 SO 4 was investigated by weight loss, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). The results show high efficiency of the inhibitors. The inhibition efficiency increases by increasing the polyethylene glycol chain length and the inhibitor concentration. From polarization curves, the inhibitors act as cathodic inhibitors. EIS spectra display a large capacitive loop at high frequencies followed by a large inductive loop at low frequencies.Environmental study shows inhibitors tendency towards biodegradation by the action of microorganisms after 28 days.