Synthesis, characterization, anti-microbial, DNA binding and cleavage studies of Schiff base metal complexes

Jayaseelan, P.; Prasad, S.; Vedanayaki, S.; Rajavel, R.

doi:10.1016/j.arabjc.2011.07.029

Cited by 59 publications

(18 citation statements)

References 23 publications

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“…The synthesized metal complexes 1-4, first stage start decomposing at 73-169 ºC with a weight loss of 9.13-9.21 %. This is in good agreement with the calculated (9.13-9.21 %) values and the percentage of weight indicating the loss of two chlorine atoms in the coordination sphere [26].…”

Section: Esi-mass Spectrasupporting

confidence: 91%

Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Metal Complexes Derived from Aniline Derivative

Priya¹,

Vedanayaki²,

Jayaseelan³

2019

Asian J. Chem.

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A new Schiff base ligand (L) N-(4-fluorophenyl)-1-(4-(((4-fluorophenyl)imino)methyl)phenyl)- methaninmine was prepared by the condensation of terephthalaldehyde with 4-fluoroaniline in 1:2 molar ratio. The mononuclear complexes of Co(II), Ni(II), Cu(II) and Zn(II) (1-4) have been synthesized in (2:1) ligand to metal ratio. The composition, geometry and binding sites of ligand with metal complexes were evidenced by various spectral methods like molar conductance, elemental analytical data, magnetic measurements, UV-visible, 1H & 13C NMR, ESI-MS, FT-IR, ESR and thermal analysis. The above studies shows that the ligand is a bidentate and its metal complexes possess an octahedral geometry. Oxidative cleavage of DNA studies of the complexes were monitored by super helix PUC18DNA using a method of agarose gel electrophoresis. Ligand and its metal complexes were screened against gram positive (Staphylococcus aureus), gram negative (Klebsiella pneumoniae) bacterium and fungus (Candida albicans) strains. Antioxidant activities of the metal complexes possess greater activity than ligand.

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Section: Esi-mass Spectrasupporting

confidence: 91%

Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Metal Complexes Derived from Aniline Derivative

Priya¹,

Vedanayaki²,

Jayaseelan³

2019

Asian J. Chem.

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“…The first copper complex reported to show efficient DNA cleavage activity bis (1,10-phenanthroline) copper(I), and then the chemistry of metal complexes of 1,10 phenanthroline or modified ligand were developed as therapeutic agents [2] . In recent years, the coordination of drugs to transition metal ions has an important role in medicine and diagnostics [3] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Ezhilarasan¹,

Krishnan²,

Arumugham³

2017

Int. J. Curr. Res. Chem. Pharm. Sci

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Ternary copper(II) complexes [Cu(phen)(L-met)EA)] 1 & [Cu(Bpy)(L-met)EA] 2 ( phen = 1,10-phenanthroline Bpy = bipyridyl, LMethionine and EA= Ethylamine), have been synthesized and characterized by CHN analysis, molar conductance, electronic absorption, IR and EPR spectral studies. They have been tested for their in vitro DNA binding activities by the spectroscopic methods such as UV-Visible, Cyclic volumetric and viscosity measurement. Further, complexes 1 and 2 displayed significant cytotoxicity when examined in-vitro on a panel of cancerous cell line -human liver cancer cell line -HepG-2 cells (IC50= 40.82 and 29.74 μg/ml). Further complexes 1 & 2 were tested for their antimicrobial activities and it was found to have good antimicrobial activities.

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“…These bands pointed out to 3 A 2 g→ 3 T 2 g, 3 A 2 g→ 3 T 1 g, and 3 A 2 g→ 3 T 1 g transitions, respectively, suggesting an octahedral geometry around the Ni atom in the complexes. This suggestion was supported by the magnetic moment measurement values of 3.42-3.56 B.M [33,34,39].…”

Section: Ni(ii) Complexesmentioning

confidence: 59%

Synthesis, Molluscicidaland Antimicrobial Potentialities of Iron Triad Mononuclear Metal Complexes Incorporating Tridentate Asymmetrical Schiff Base Ligands Containing Soft Sulfur Coordinating Atom

Alosaimi¹,

Mannoubi²,

Zabin³

2019

Asian J Pharm Clin Res

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Objective: This work aimed at synthesizing tridentates asymmetrical Schiff base ligands containing sulfur atom and using them for preparing metal complexes with the iron triad metals. The prepared compounds were assayed in vitro for antimicrobial potential and in vivo molluscicidal activity. Methods: The unsymmetrical tridentate Schiff bases (SL1, SL2, and SL3) were prepared using 2-aminothiophenol as primary amine and condensed with 2-carboxybenzaldehyde, 2-hydroxy-1-naphthaldehyde, and 7-formyl-8-hydroxyquinoline. These ligands were used in preparing metal complexes with iron triad metals. The synthesized Schiff base ligands and their corresponding metal complexes were characterized and their proposed structures were confirmed using different physical and spectroscopic analytical techniques. All ligands and their corresponding metal complexes were assayed against different bacterial and fungal strains using the agar disk-diffusion technique. The molluscicidal activity was performed according to the standard reported methods as cited in the literature and by observing the toxicity and lethal dose according to the WHO guidelines. Results: The synthesized ligands behave as tridentate (NOS) ligands and form mononuclear complexes with the general formula [M(SL)2] with an octahedral geometry around the central metal ion. Metal complexes were non-electrolytic in nature. The in vitro antibacterial and antifungal examination results showed weak activity of the ligands, and there was enhanced activity with the complexes. The in vivo molluscicidal activity of the tested compounds showed good activity. Conclusion: The targeted compounds were prepared successfully, characterized, and showed some biological activity but lower than the standard reference drugs.

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Synthesis, characterization, anti-microbial, DNA binding and cleavage studies of Schiff base metal complexes

Cited by 59 publications

References 23 publications

Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Metal Complexes Derived from Aniline Derivative

Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Metal Complexes Derived from Aniline Derivative

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Synthesis, Molluscicidaland Antimicrobial Potentialities of Iron Triad Mononuclear Metal Complexes Incorporating Tridentate Asymmetrical Schiff Base Ligands Containing Soft Sulfur Coordinating Atom

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