Synthesis, characterization, antimicrobial activity and structure–activity relationships of new aryldisulfonamides

Alyar, Saliha; Karacan, Nurcan

doi:10.1080/14756360802561220

Cited by 35 publications

(20 citation statements)

References 34 publications

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“…25,26 In NMR spectra, aromatic proton peaks were observed at about 6.78-7.96 ppm, and aromatic carbon peaks were shown at 108.54-160.72 ppm. The chemical shi of the NH group of the compounds in DMSOd 6 is in the range of 8.25-9.77 ppm.…”

Section: Chemistrymentioning

confidence: 97%

4-Hydroxy-3-methoxy-benzaldehyde series aroyl hydrazones: synthesis, thermostability and antimicrobial activities

et al. 2014

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Efficient synthetic procedures for the preparation of aroyl hydrazones were developed by converting the corresponding ethyl ester into hydrazides, followed by a reaction with 4-hydroxy-3-methoxybenzaldehyde. A series of aromatic hydrazides and aroyl hydrazones were characterized by elemental analysis, IR, 1 H NMR, 13 C NMR and thermogravimetric analysis. The thermal gravity analysis showed that the compounds 3a-3d were stable below 228.23, 227.65, 118.97 and 179.51 C, respectively. The aromatic hydrazides and aroyl hydrazones showed antimicrobial activity towards Staplylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The antibacterial activity experiments indicated that aroyl hydrazones had higher activity than the hydrazides. The presence of a hydroxyl group, as well as the number and position of the hydroxyl groups, were important and further enhance the antimicrobial activity.

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Section: Chemistrymentioning

confidence: 97%

4-Hydroxy-3-methoxy-benzaldehyde series aroyl hydrazones: synthesis, thermostability and antimicrobial activities

et al. 2014

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“…The biological activities were shown to depend on the nature of the moiety present at the 9-position of the central pyran ring. The introduction of a phenyl sulfonamide at the above position gave rise to derivatives with antimicrobial [9] [10], antimalarial [11] [ 12], and antibacterial activities [13] [14] [15] [16]. The replacement of the sulfonamide with a carboxamide generated derivatives with similar activity profile as those of sulfonamide but also displayed fungicidal activity [17].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Bis-Trifluoromethyl 1,8-Dioxo-Octahydroxanthene Derivatives

Okoro¹,

Ogunwale²,

Oyedele³

2019

IJOC

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Xanthene and Xanthenediones are structural components of several bioactive and semi-synthetic molecules. This work described an expeditious synthesis of novel and hitherto unreported bis-trifluoromethyl xanthene dione derivatives. The reaction of two equivalents of 5-trifluoromethyl cyclohexane-1,3dione with substituted aromatic aldehydes in the presence of ethanol containing 1 -2 drops of HCl was facile under microwave irradiation. Short reaction time (25 min), good to excellent yields (80% -95%), good atom economy, and simple workup are the major advantages of the above procedure. Moreover, the fluorinated products represent synthetically useful stable intermediates that could find applications in pharmaceutical, agricultural and material industries.

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“…In our previous studies, aliphatic and aromatic disulfonamides were synthesized and evaluated for antimicrobial activity (Ozbek et al, 2007a, b;Alyar and Karacan, 2009;Alyar et al, 2007). In addition, methanesulfonic acid hydrazides and their hydrazones were obtained and screened for their antimicrobial and cytotoxic activity (Ienco et al, 1999;Dodoff et al, 1999;Alyar et al, 2008;Ozbek et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Quantitative structure–activity relationships studies for prediction of antimicrobial activity of synthesized disulfonamide derivatives

et al. 2010

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A new series of disulfonamides were synthesized and assayed as antimicrobial agents against Staphylococcus aureus, Bacillus cereus, and Escherichia coli. The quantitative structure-activity relationship analysis (QSAR) was applied to find out the correlation between experimentally evaluated antimicrobial activities with various parameters of the compounds using stepwise multiple liner regression method. The QSAR analysis revealed that the third-order average connectivity index 3 v A ð Þ was found to have negative correlation. The best QSAR models were further validated by leave-one-out method of cross-validation.

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Synthesis, characterization, antimicrobial activity and structure–activity relationships of new aryldisulfonamides

Cited by 35 publications

References 34 publications

4-Hydroxy-3-methoxy-benzaldehyde series aroyl hydrazones: synthesis, thermostability and antimicrobial activities

4-Hydroxy-3-methoxy-benzaldehyde series aroyl hydrazones: synthesis, thermostability and antimicrobial activities

Facile Synthesis of Bis-Trifluoromethyl 1,8-Dioxo-Octahydroxanthene Derivatives

Quantitative structure–activity relationships studies for prediction of antimicrobial activity of synthesized disulfonamide derivatives

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