Synthesis, Characterization, Antimicrobial and Anticancer Activities of 14-Membered Macrocyclic Schiff Base Metal Complexes

Abstract

New cationic 14-membered macrocyclic Schiff base metal complexes have been synthesized by condensation of benzalidene-curcuminyl-4-iminoantipyrine and 2,6-diaminopyridine. Structural characterization of the compounds was done using elemental analysis, molar conductivity, magnetic susceptibility, Mass, SEM, XRD, 1 H NMR, UV-visible, IR and EPR spectra. X-ray diffraction patterns suggested that the size of Schiff base is reduced due to chelation by the metal ion. Different morphologies of synthesized compounds were identified by SEM images. Magnetic moment values, UV-visible and IR spectral studies confirms the square planar geometry of chelates. However [VOL]Cl2 exists in octahedral geometry. Electron spin resonance spectra parameters of [CuL]Cl2 and [VOL]Cl2 complexes were well coinciding with proposed geometries. The in vitro biocidal activities of the compounds were done against some bacterial and fungal strains by disc diffusion method. Anticancer activity of Schiff base and copper complex were carried out by MTT method which reveals that the inhibition against the growth of breast cancer cell line culture for chelate is higher than Schiff base.

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

“…35 In addition, further evidence for the formation of Schiff base (L) and C4 complex was obtained from the NMR spectra. The attained 1 H and 13 C NMR values of C4 complex were compared with the corresponding ligand and were in good agreement with the proposed structure of the C4 complex. The 1 H and 13 C NMR spectra of the ligand and C4 complex have been given in ESI.…”

“…9 Due to their astonishing structural properties and varied denticities, Schiff bases have received considerable attention for many years and these properties have resulted in their wide application in the clinical, biological, analytical and pharmaceutical elds. [10][11][12][13] The coordination of transition metals to these scaffolds increases their biological activities and lowers the cytotoxicity of both metal and the ligand. [14][15][16] Schiff base metal complexes are gaining considerable attention due to their potential antifungal, antitumor and antibacterial activities.…”

Bioactivity and DNA/BSA Interactions of Selenium N‐Heterocyclic Carbene Adducts

“…Therefore, this titrimetry is a key basement tool to study drug-DNA affinity. [47] This interaction for selenium adducts (1 s-4 s) was studied while monitoring the change in absorbance when concentration of ct-DNA was increased (1 × 10 À 5 À 6 × 10 À 5 M) and results are reported in intrinsic binding constant, Table 2.…”

New copper(II) and zinc(II) complexes based on azo Schiff base ligand: Synthesis, crystal structure, photoisomerization study and antibacterial activity

“…Schiff base derivatives are useful compounds that have many applications. They have been playing vital roles in the pharmaceutical industry as antimicrobials, antidepressants, cytotoxics, analgesics, antileischmanials, anticonvulsants and fungicides and as anti‐inflammatory and anticancer agents . In coordination chemistry, Schiff bases constitute privileged ligands that can form stable complexes with transition metals .…”

“…They have been playing vital roles in the pharmaceutical industry as antimicrobials, [19][20][21] antidepressants, [22] cytotoxics, [23] analgesics, [24] antileischmanials, [25] anticonvulsants [26] and fungicides [27,28] and as anti-inflammatory [29] and anticancer agents. [30] In coordination chemistry, Schiff bases constitute privileged ligands that can form stable complexes with transition metals. [31][32][33][34][35] Among these, Schiff base complexes of copper and zinc, which are essential elements for humans with their several biological activities, are of paramount scientific interest.…”