Synthesis, characterization, antimicrobial and antitumor reactivity of new palladium(II) complexes with methionine and tryptophane coumarine derivatives

Stojković, Danijela Lj.; Jevtić, Verica V.; Vuković, Nenad; Vukić, Milena; Čanović, Petar; Zarić, Milan; Mišić, Milena M.; Radovanovic, Dragce; Baskić, Dejan; Trifunović, Srećko R.

doi:10.1016/j.molstruc.2017.12.095

Cited by 18 publications

(6 citation statements)

References 24 publications

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“…28 Developing a direct method for the simple, efficient, and green construction of particular heterocyclic motifs that makes use of available materials remains an ongoing challenge for chemists from both a synthetic and mechanistic perspective. Among the many available construction strategies, [29][30][31][32][33][34][35][36][37] microwave-assisted synthesis of heterocyles is perhaps the most promising. Herein, we introduce a novel and simple method for the synthesis of substituted pyran-2,4-dione and its conversion into β-enamino-pyran-2,4-diones.…”

Section: Introductionmentioning

confidence: 99%

A novel synthetic approach to pyran-2,4-dione scaffold production: Microwave-assisted dimerization, cyclization, and expeditious regioselective conversion into β-enamino-pyran-2,4-diones

Sarhan

Haukka

Barakat

et al. 2020

Tetrahedron Letters

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Section: Introductionmentioning

confidence: 99%

A novel synthetic approach to pyran-2,4-dione scaffold production: Microwave-assisted dimerization, cyclization, and expeditious regioselective conversion into β-enamino-pyran-2,4-diones

Sarhan

Haukka

Barakat

et al. 2020

Tetrahedron Letters

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“…The intensity of the antibacterial action of ligands and complexes depends upon the type of species of microorganisms. The tested complexes significantly showed lower antibacterial activity compared to commercial antibiotics [67,68].…”

Section: Antibacterial Susceptibility Studymentioning

confidence: 89%

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

Dev

Sahu

Chaudhary

et al. 2023

J. Nepal Chem. Soc.

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The two new novel heteroleptic complexes of the type [M(II)L1.L2] (M= Zr(II) & Pd(II), L1= oxytetracycline (Otc), and L2=salicylaldehyde (Sal)) have been synthesized and analyzed by physical measurements such as CHN, pH, and conductivity. The conductivity data revealed the electrolytic nature of Pd(II)Otc/Sal and the non-electrolytic nature of the Zr(II)Otc/Sal metal complex of mixed ligand. The structural characterizations of the metal complex were approved by spectroscopic analysis methods, such as IR, 1H & 13C-NMR, UV/ Visible, and ESI-MS studies. Thermal analysis (TGA/DTA) determines the thermal and kinetic stabilities of the metal complexes using a popular Coats-Redfern equation through which the activation parameters can be calculated easily. SEM can determine the surface morphology of metal complexes. The selected bond lengths, bond angles, final optimized energy, and geometry of complexes were obtained by running an optimization task in the 3D molecular modeling software program via Chem 3D Pro. 12.0.2. The final geometrical energy was found to be 921.7712 for Zr(II)Otc/Sal and 914.6006 Kcal/mol for Pd(II)Otc/Sal complexes. Based on the above study, Zr(II)Otc/Sal complex has tetrahedral geometry and the Pd(II)Otc/Sal complex has square planar geometry. The complexes were tested in vitro for antibacterial susceptibility study against various strains of clinical pathogenic bacteria such as Staphylococcus aureus (Gram-positive), Proteus mirabilis, and Escherichia coli (Gram-negative). For the antibacterial study, the Kirby-Bauer paper disc diffusion technique is applied by using 50, 25, and 12.5 μg/μL concentrations of the metal complex. Good antibacterial sensitivity was found against all tested pathogens in all synthesized complexes.

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“…1). [31][32][33][34][35][36][37][38] In many cases palladacycles have demonstrated an activity that is several orders higher relative to Pt-complexes, while maintaining a less cytotoxic effect on healthy cells. Nevertheless, to date, no palladium complex has been approved for use as an anticancer drug.…”

Section: Introductionmentioning

confidence: 99%

Bilateral metalloheterocyclic systems based on palladacycle and piperidine-2,4-dione pharmacophores

et al. 2023

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Synthesis, characterization, antimicrobial and antitumor reactivity of new palladium(II) complexes with methionine and tryptophane coumarine derivatives

Cited by 18 publications

References 24 publications

A novel synthetic approach to pyran-2,4-dione scaffold production: Microwave-assisted dimerization, cyclization, and expeditious regioselective conversion into β-enamino-pyran-2,4-diones

A novel synthetic approach to pyran-2,4-dione scaffold production: Microwave-assisted dimerization, cyclization, and expeditious regioselective conversion into β-enamino-pyran-2,4-diones

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

Bilateral metalloheterocyclic systems based on palladacycle and piperidine-2,4-dione pharmacophores

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