Synthesis, characterization, antimicrobial, and DNA cleavage evaluation of some organotin(IV) complexes derived from ligands containing the 1H-indole-2,3-dione moiety

Abstract

Sn), and ultraviolet-visible light spectroscopic studies. The spectroscopic data showed that the ligands are monobasic bidentate, coordinating through nitrogen and sulfur/oxygen atoms. Thus, suitable trigonal bipyramidal geometry and octahedral geometry have been suggested for the 1:1, and 1:2 metal complexes, respectively. The ligands and their complexes have been tested against various microbes for their in vitro antimicrobial activities. All complexes exhibit good antibacterial activity against the two bacterial species Escherichia coli and Staphylococcus aureus and remarkable antifungal activity against the two fungi Fusarium semitectum and Aspergillus flavus with respect to their corresponding ligands. The DNA cleavage efficiency of the ligands and the complexes has also been examined and discussed using gel electrophoresis technique, which showed the cleavage of DNA by all the metal complexes and ligands.

Design, synthesize, physicochemical characterization, nonlinear optical properties structural elucidation, biomedical studies, and DNA interaction of some new mixed ligand complexes incorporating 4,6‐dimethylpyrimidine derivative and imidazole ligand

“…The intense absorption bands at (1672, 1656, 1619, and 1609 cm À1 ) viewed in the FT-IR spectra of the studied mixed ligand chelates (Figure S1 and Table 1) might be recognized to the ν(C=N) imine group. The detected negative, as well positive shift through (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) for ν(C=N) of the studied complexes as compared to 1639 cm À1 of the BIP ligand obviously idea to the involvement of ν(C=N) atoms in chelation with studied metal salts. 36 Also, the characteristic band of ν(N-H) in the pyrimidine ring related to the BIP ligand at 3252 cm À1 exhibited that all prepared mixed ligand chelates on a scale of 3671-3130 cm À1 correspond to the nitrogen atoms in the NH group, which the chelation about the metal salts.…”

“…In complexation chemistry, (benzimidazole and pyrimidine) products and chelates own many pharmacologic possessions comprising anti-HIV, antileprosy, anticonvulsant, antileukemic, and anti-anxiety behaviors due to their definite structural properties. 21,22 Chelation of metal salts are identified to improve drug mechanism as well as expand antimicrobial performances of bio-medical ligands. 23 Though, to evidently recognize the task of metal salts towards organisms, the structural geometry as well as interacting with biological structures for several metal chelates medicines must be explored.…”

Synthesis, Biological Activity and QSAR Studies of Organotin(IV) and Organosilicon(IV) Complexes

“…In the 29 Si NMR spectra, sharp peaks were observed at δ −13.37 to δ −20.2 ppm . Similarly in the 119 Sn NMR spectra, chemical shift values were obtained in the range δ −143.97 to δ −156.21 ppm, which clearly showed penta‐ coordinated environment around the silicon and tin atoms (Figure ).…”

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“…This is because due to chelation, the polarity of metal complexes decreases and lipophilic nature increases which thereupon favor its penetration through the lipid coating of the cell membrane and inhibit the activity of enzymes which denatured the proteins. Such improved activity of the complexes can be explained based on the overtone concept and the tweedy chelation theory 22 .…”