Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives

Abstract

The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The search for better pharmacological active drug and the importance of disubstituted 1,3,4-oxadiazole and 1,3,4-thiadiazole as active pharmacophores, prompted us to design, synthesize, characterize, and evaluate a series of differently substituted sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole for their potential antimicrobial, analgesic and antiinflammatory activity, respectively. New sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives were synthesized by intramolecular cyclization of thiosemicarbazide in alkaline medium. Reactions were carried out by the reaction between aromatic carbonyl halide and thiosemicarbazide.

Novel Bridgehead Thiadiazolopyrimidine Derivatives with Antimicrobial and Antitumor Activities

“…The antimicrobial activities were conducted at the Regional Center for Mycology and Biotechnology, Al‐Azhar University, Cairo, Egypt. Compounds 1a , b were previously prepared by Pal et al . and Vachala and Bhargavi .…”

Molecular Structure Vibrational & Electronic Properties of Some Isatin Derivatives

“…The isatin ring system consists of a benzene ring fused to a five-membered pyrrole ring [1]. Isatin, or 1H-indole-2,3-dione, containing both the keto and amide groups [2] (Fig. 1), is a derivative of indole at the second and third positions of the ring [3].…”

Design,in silicostudies, and synthesis of new 1,8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects

“…Heterocyclic synthesis has become a powerful technique in organic synthesis for generating new molecules for drug discovery and development. [1][2][3][4][5][6][7][8] Nitrogen atom-containing heterocyclic compounds provide highly functionalized scaffolds on which pharmacophoric features can be arranged to obtain effective and selective drugs. [9][10][11][12][13][14][15][16][17] Histamine is one of the most important chemical mediators that inuences immune regulation via an acute and chronic inammatory response through 4 different types of G-protein coupled receptors, H1, H2, H3, and H4.…”