Synthesis,Characterization, biocidal, Anti-diabetic, Anti-inflammatory and Anti-Cancer(MCF-7) Studies of Schiff base ligand and its metal (II) complexes

Abstract

A new Schiff base ligand (L1) was prepared from 3-aminoquinoline with 2, 5 dimethoxybenzaldehyde in 1:1 molar ratio. Two different co-ordination of mononuclear metal(II) complexes [(ML1) &(ML1L2)] [ M= Co(II), Ni(II), Cu(II) and Zn(II)] were synthesized & characterized. ML1wereprepared from L1 and metal acetate salts molar proportion One:Two. ML1L2 synthesized from L1, metal salts and 8-hydroxy quinoline (L2) molar ratiois 1:1:1. Elemental analyses, IR, NMR, Electronic spectra, Mass spectra, EPR, SEM and Powder XRD &molar conductivity are need to clarify the structure of synthesized metal(II) complexes. The squareplanar geometry is proposed for CuL1, NiL1, ZnL1, NiL1L2 and ZnL1L2, tetrahedral geometry for CoL1&CoL1L2 and distorted square planar geometry for CuL1L2complex. Powder XRD reveals that L1, ML1& ML1L2 have crystalline nature. Antibacterial activity of Ligand,ML1& ML1L2 were screened against bacterium Gram(+), Gram(-) &antifungal activity was determined against fungus. Theanti-inflammatory and anti-diabetic actions of the L1, CuL1 &CuL1L2complexes were studied. Theanticancer activity of L1, CuL1 and CuL1L2 were studied opposed toMCF-7 using MTT assay method.

Synthesis, Spectral Characterization on Bioactive Complexes Containing Schiff Base Ligand.

“…Drug-binding sites are provided by the complex's metal ions in the centre. Several compounds showed antibacterial, antitumor, anticancer, antifungal properties adding to the growing body of evidence that these compounds represent a significant class of molecules with important medical and pharmaceutical applications [12][13][14][15][16][17] . Schiff bases biological action derives from the azomethine bond.…”