Synthesis, characterization, DNA-binding and DNA-photocleavage studies of [Ru(bpy)2(pmip)]2+ and [Ru(phen)2(pmip)]2+ (pmip=2-(2′-pyrimidyl)imidazo[4,5-f][1,10]phenanthroline

Shi, Shuo; Xie, Tian; Yao, Tianming; Wang, Chao-Ran; Geng, Xiao-Ting; Yang, Danjing; Han, Linjie; Ji, Liang‐Nian

doi:10.1016/j.poly.2009.02.035

Cited by 26 publications

(4 citation statements)

References 38 publications

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“…Therefore, a detailed understanding of the interaction of ruthenium compounds with models of binding sites present in DNA is of paramount significance to unravel the mechanism of action of ruthenium-derived complexes . During the past decade, a huge amount of work has been published on the synthesis, cytotoxicity, and DNA-binding ability of Ru(II) compounds. − …”

Section: Dna Binding Protein Binding and Apoptosis Of Ruthenium Compo...mentioning

confidence: 99%

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

et al. 2018

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Metal based therapeutics are a precious class of drugs in oncology research that include examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and therapeutics applications. Ruthenium compounds have shown selective bioactivity and the ability to overcome the resistance that platinum-based therapeutics face, making them effective oncotherapeutic competitors in rational drug invention approaches. The development of antineoplastic ruthenium therapeutics is of particular interest because ruthenium containing complexes NAMI-A, KP1019, and KP1339 entered clinical trials and DW1/2 is in preclinical levels. The very robust, conformationally rigid organometallic Ru(II) compound DW1/2 is a protein kinase inhibitor and presents new Ru(II) compound designs as anticancer agents. Over the recent years, numerous strategies have been used to encapsulate Ru(II) derived compounds in a nanomaterial system, improving their targeting and delivery into neoplastic cells. A new photodynamic therapy based Ru(II) therapeutic, TLD-1433, has also entered clinical trials. Ru(II)-based compounds can also be photosensitizers for photodynamic therapy, which has proven to be an effective new, alternative, and noninvasive oncotherapy modality.

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Section: Dna Binding Protein Binding and Apoptosis Of Ruthenium Compo...mentioning

confidence: 99%

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

et al. 2018

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“…Stern-Volmer quenching constants for complexes 1-4 in the absence and presence of DNA are given in Table 3. Intercalation of small molecules into the double helix is known to increase the helix melting temperature (T m ), [59,[77][78][79][80][81][82] the temperature at which the double helix denatures into single-stranded DNA. However, in the presence of DNA, the maximum decreases in the Stern-Volmer quenching constant are obtained for complexes 3 and 4, indicating strong binding of these complexes.…”

Section: Dna-binding Studiesmentioning

confidence: 99%

“…[72,[74][75][76] DNA melting experiments: Further evidence for intercalation of the complexes into the helix was obtained from DNA melting studies. Intercalation of small molecules into the double helix is known to increase the helix melting temperature (T m ), [59,[77][78][79][80][81][82] the temperature at which the double helix denatures into single-stranded DNA. The extinction coefficient of DNA bases at 260 nm in the double-strand is much lower than that in the single-stranded form; hence, melting of the helix leads to an increase in the absorption at this wavelength.…”

Section: Dna-binding Studiesmentioning

confidence: 99%

Efficient DNA Condensation Induced by Ruthenium(II) Complexes of a Bipyridine‐Functionalized Molecular Clip Ligand

Bhat

Kumbhar

Khan

2012

Chemistry A European J

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Complexes of the type [Ru(bxbg)(2) (N-N)](2+), where N-N denotes 2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), dipyrido[3,2-d:2',3-f] quinoxaline (dpq) (3), and dipyrido[3,2-a:2',3'-c]phenazine (dppz) (4), incorporating bis(o-xylene)bipyridine-glycoluril (bxbg) as an ancillary "molecular clip" ligand, have been synthesized and characterized. These ruthenium(II) complexes of bis(o-xylene)bipyridine-glycoluril self-associate in water through specific molecular recognition processes to form polycationic arrays. These arrays containing electrostatic binders as well as intercalator ligands at micromolar doses rapidly condense free DNA into globular nanoparticles of various sizes. The DNA condensation induced by these complexes has been investigated by electrophoretic mobility assay, dynamic light scattering, and transmission electron microscopy. The cellular uptake of complex-DNA condensates and the low cytotoxicity of these complexes satisfy the requirements of a gene vector.

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“…The thermal melting of DNA is widely used to measure the thermostability of the double helix [21,22]. If the buffer solution of DNA was heated at a properly elevated temperature its double strands will dissociate, the corresponding single stands will form, and the absorbance of the solution will increase.…”

Section: Melting Temperature Of Ct Dna Without and With 4fmentioning

confidence: 99%