Synthesis, characterization, DNA binding properties and antioxidant activity of a manganese(II) complex with NO6 chromophore

Karastogianni, Sophia; Dendrinou‐Samara, Catherine; Ioannou, Eleutheria; Raptopoulou, Catherine P.; Hadjipavlou-Litina, Demetra; Girousi, Stella

doi:10.1016/j.jinorgbio.2012.09.015

Cited by 31 publications

(18 citation statements)

References 67 publications

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“…It is this interaction that greatly affects and/or damages DNA conventional behavior and so that these transition metal complexes possess a very broad application background in the field of bio-inorganic chemistry [27][28][29]. Hence, studies of the interaction between transition metal complexes and DNA have been pursued in recent years [30][31][32][33], particularly oxovanadium(IV) complexes, which can bind and cleave DNA [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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“…To the best of our best knowledge, this is the first use of this complex as an electro-chemical modifier of electrode surfaces, in this case CPE, forming a stable polymer on its surface, and the first application of the resulted electrode to the determination of B 12 . Evidently, manganese complex was found to both intercalate with DNA through π-π* stacking interactions of thiophenyl groups, making the immobilization of dsDNA on the modified CPE with manganese complex easier [40,41]. By applying this novel electrode surface to the determination of B 12 , the analytical features were improved, showing relatively broad linear range as well as low detection and quantification limits.…”

Section: Introductionmentioning

confidence: 99%

“…This biosensor is based on the modification of carbon paste electrode (CPE) with an electrochemically produced deposit of a manganese(II) complex, i.e. [Mn(thiophenyl-2-carboxylic acid) 2 (triethylonamine)] (A), which was found to intercalate with DNA [40,41]. The modified surface of carbon paste electrode with the polymer of (A) was used on the immobilization of calf thymus dsDNA.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of these features renders this approach suitable as a general platform for the detection of other biomolecules or hybridization events in DNA biosensors without the need for labeled sequences. [40]. Stock solutions of 3 g/L of (A) were prepared after weighing a certain amount of the compound and dilution in dimethyl sulphoxide.…”

Section: Introductionmentioning

confidence: 99%

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Development of an electrochemical DNA biosensor for the detection of vitamin B12 (cyanocobalamin) at a carbon paste modified electrode with a manganese(II) complex

Dimitropoulou¹,

Karastogianni²,

Girousi³

2017

J Appl Bioanal

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“…Thiophene carboxylic acid (HTPC) also has potential in the preparation of DNA hybridization indicators, single-molecule magnets, photoluminescence materials and treatment of osteoporosis as inhibitors of bone resorption in the tissue culture (Drozdzewski et al, 2004a,b;Yuan et al, 2004;Feng et al, 2005;Panagoulis et al, 2007;Boulsourani et al, 2011a,b;Zhou et al, 2011;Karastogianni et al, 2013;Kuchtanin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Structural elucidation of novel mixed ligand complexes of 2-thiophene carboxylic acid [M(TCA)2(H2O)x(im)2] [x=2 M: Mn(II), Co(II) or Cd(II), x=0 Cu(II)]

Taş

Topal

Çamur

et al. 2014

Main Group Metal Chemistry

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Novel mixed ligand complexes containing thiophene-2-carboxylic acid (HTCA) and imidazole (im) ligands, [M(TCA) 2 (H 2 O) 2 (im) 2 ] (M: Mn, Co, Cd) and [Cu(TCA) 2 (im) 2 ] were obtained. The complexes were characterized by X-ray single crystal diffraction. Also, spectroscopic (IR and UV-Vis), magnetic and thermal properties were investigated. The thiophene-2-carboxylate acted in a monoanionic monodentate manner and bonded to the metals via its carboxylate oxygen. The im ligands bonded to the metals via hydrogen free nitrogen atoms. The geometry around the metal centers was octahedral [MO 4 N 2 ] for Mn(II), Co(II) and Cd(II) complexes and square-planar [CuO 2 N 2 ] for the Cu(II) complex. Due to intermolecular interactions in the solid state, the Co(II), Mn(II) and Cd(II) complexes showed three-dimensional networks, while the copper complex was a one-dimensional network. In consideration of the anhydrous form of the complexes, the thermal stability of the complexes was of the following order: Co (273°C) > Cu (229°C) > Cd (175°C) > Mn (167°C).

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Synthesis, characterization, DNA binding properties and antioxidant activity of a manganese(II) complex with NO6 chromophore

Cited by 31 publications

References 67 publications

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Development of an electrochemical DNA biosensor for the detection of vitamin B12 (cyanocobalamin) at a carbon paste modified electrode with a manganese(II) complex

Structural elucidation of novel mixed ligand complexes of 2-thiophene carboxylic acid [M(TCA)2(H2O)x(im)2] [x=2 M: Mn(II), Co(II) or Cd(II), x=0 Cu(II)]

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