Synthesis, characterization, photoluminescence properties and cytotoxic activities of Sm(III) complexes of β-diketones

Sarıoğlu, Ahmet Oral; Kahraman, Demet; Köse, Ayşegül; Sönmez, Mehmet

doi:10.1016/j.molstruc.2022.132786

Cited by 16 publications

(4 citation statements)

References 49 publications

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“…The remarkable redox stability of lanthanide compounds allows them to withstand the influence of various biological factors, such as thiols and ascorbic acid. Consequently, they hold great potential as promising candidates for future antitumor medications ( Sudha and Enoch, 2011 ; Natesan et al, 2014 ; Sudha et al, 2015a ; Sudha et al, 2015b ; Chandrasekaran et al, 2015 ; Aramesh-Boroujeni and Jahani, 2020 ; Song et al, 2020 ; Sarıoğlu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: In vitro BSA-binding, antimicrobial, and antitumor activity against human cancer cell lines of two lanthanide (III) complexes

et al. 2023

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The investigation involved examining the binding of two lanthanide complexes, specifically those containing Holmium (Ho) and Dysprosium (Dy), with a ligand called 1, 10-phenanthroline (phen), and bovine serum albumin (BSA). The evaluation was carried out utilizing fluorescence measurements, Förster theory, and docking studies. The findings indicated that both the Ho-complex and Dy-complex possessed a significant ability to quench the emission of the protein. Furthermore, the primary mechanism of interaction was identified as a static process. The Kb values indicate a strong tendency of these complexes for binding with BSA. The Kb values show the strangely high affinity of BSA to complexes and the following order for binding affinity: Ho-complex > Dy-complex. The thermodynamic parameters were found to be negative, affirming that the main forces driving the interaction between BSA and the lanthanide complexes are van der Waals engagement and hydrogen bonds. Additionally, the investigation included the examination of competition site markers, and molecular docking proposed that the engagement sites of the Ho-complex and Dy-complex with BSA were predominantly located in site 3 (specifically, subdomain IB). Moreover, the Ho-complex and Dy-complex were specifically chosen for their potential anticancer and antimicrobial properties. Consequently, these complexes could present promising prospects as novel candidates for anti-tumor and antibacterial applications.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: In vitro BSA-binding, antimicrobial, and antitumor activity against human cancer cell lines of two lanthanide (III) complexes

et al. 2023

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Section: Resultsmentioning

confidence: 99%

“…The results have also shown that the newly prepared compounds exhibit strong inhibition activity on tested cell lines with respect to standard antitumor drugs and literatureprepared antitumor compounds. 24,[47][48][49] At rst sight to cytotoxic values, the pure Sm(III) nanocomplex has higher activity than its electrospun bers. However, a deeper look at these values shows that the electrospun bers of Sm(III) nanocomplex is more active than pure ones.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

“…1 Till now, the majority of reports about Sm(III) complexes and their biomedical applications are in the bulk state. [24][25][26][27][28][29] The reports about the incorporation of Sm(III) complexes into polymeric nanobers are, however, limited. Therefore, an essential goal of the present study is the fabrication of a drug delivery system by preparation of electrospinning bers (as a biocompatible drug carrier) with loading Sm(III) nanocomplex, their antitumor activities were evaluated both in vitro on tumor cell lines and in vivo on tumor-bearing mice.…”

Section: Introductionmentioning

confidence: 99%

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Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Fouad

Ali

2023

RSC Adv.

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Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells

Yang,

Li,

et al. 2024

Drug Development Research

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Four lanthanide complexes with 8‐hydroxyquinoline‐2‐aldehyde‐2‐hydrazinopyridine (H‐L1), 8‐hydroxyquinoline‐2‐aldehyde‐2‐hydrazimidazole (H‐L2): [Sm(L1)2][Sm(L1)(NO3)3]·CHCl3·2CH3OH (1), [Gd(L1)2][Gd(L1)(NO3)3]·CHCl3·2CH3OH (2), [Sm(L2)(NO3)2]2·CH3OH (3), and [Eu(L2)(NO3)2]2·CH3OH (4) were synthesized and characterized. In vitro cytotoxicity evaluation showed that the ligands and four lanthanide complexes exhibited cytotoxicity to the five tested tumor cell lines. Among them, complex 1 showed the best antiproliferative activity against NCI‐H460 tumor cells. Mechanistic studies demonstrated that complex 1 arrested the cell cycle of NCI‐H460 cells in G1 phase and induced mitochondria‐mediated apoptosis, which resulted in the loss of mitochondrial membrane potential, enhanced intracellular Ca2+ levels and reactive oxygen species generation. In addition, complex 1 affected the expression levels of intracellular apoptosis‐related proteins and activated the caspase‐3/9 in NCI‐H460 cells. Therefore, complex 1 is a potential anticancer agent.

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Synthesis, characterization, photoluminescence properties and cytotoxic activities of Sm(III) complexes of β-diketones

Cited by 16 publications

References 49 publications

RETRACTED: In vitro BSA-binding, antimicrobial, and antitumor activity against human cancer cell lines of two lanthanide (III) complexes

RETRACTED: In vitro BSA-binding, antimicrobial, and antitumor activity against human cancer cell lines of two lanthanide (III) complexes

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells

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