Synthesis, crystal structure and action on Escherichia coli by microcalorimetry of copper complexes with 1,10-phenanthroline and amino acid

Li, Xi; Zhang, Zhijun; Wang, Chenggang; Zhang, Tian; He, Kai; Deng, Fanghao

doi:10.1016/j.jinorgbio.2010.09.001

Cited by 25 publications

(9 citation statements)

References 42 publications

(46 reference statements)

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“…The differences between  asy (OCO) and  sym (OCO) stretching frequencies of all the metal complexes were found to be greater than that of the ligand as reported in Table 3. This confirms the monodentate mode of coordination of the carboxylate group to the central metal through the hydroxyl oxygen atom via deprotonation [23][24][25][26][27]. This is in good agreement with an earlier study on the same ligand where an X-ray single crystal was obtained [9].…”

Section: Fourier Transform Infra-red Spectra (Ftir)supporting

confidence: 91%

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Osunniran¹,

Obaleye²,

Tella³

et al. 2021

Bull. Chem. Soc. Eth.

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Transition metal complexes of Cu(II), Co(II) and Ni(II) with eflornithine hydrochloride hydrate (EFN), an antitrypanosomiasis drug, as ligand have been synthesized and characterized by melting point, elemental analysis, Fourier transform infrared (FTIR), electronic spectra, magnetic susceptibility and electrospray ionization mass spectrometry (ESI-MS). The FTIR spectral data suggested the coordination modes of the ligand to be bidentate, coordinated to the metal ions through its carboxylate oxygen atom and an amino nitrogen atom. From the microanalytical data, the stoichiometry of the metal complexes is 1:2 (metal to ligand). The electronic absorption and magnetic susceptibility studies generally suggested octahedral geometry for the metal complexes. Toxicological evaluation of the ligand (EFN) and complexes were carried out using albino rats. Twenty-five albino rats that were used for the experiment were randomly divided into five groups and animals in group 1 served as a control. All the animals were sacrificed twenty-four hours after completion of their doses. The results revealed a high level of toxicity of EFN than the synthesized metal complexes. KEY WORDS: Eflornithine hydrochloride hydrate, Carboxylate moiety, Antitrypanosomiasis drug, Toxicological evaluation, Albino rats Bull. Chem. Soc. Ethiop. 2020, 34(3), 489-500. DOI: https://dx.doi.org/10.4314/bcse.v34i3.6

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Section: Fourier Transform Infra-red Spectra (Ftir)supporting

confidence: 91%

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Osunniran¹,

Obaleye²,

Tella³

et al. 2021

Bull. Chem. Soc. Eth.

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“…This elongation can be explained by the Jahn-Teller effect [19]. The Cu1eN phen (1.994(2) and 1.976(2)Å), Cu1eN2 (2.025(2) Å) and Cu1eO1 (1.970(2) Å) bond distances are normal and are comparable to those found for the related copper(II) complexes [31,[38][39][40][41].…”

Section: Crystal Structuresupporting

confidence: 67%

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

Paixão

Marzano

Jaimes

et al. 2017

Journal of Inorganic Biochemistry

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Five new copper(II) complexes of the type [Cu(NO)(NN)(ClO)], in which NO=4-fluorophenoxyacetic acid hydrazide (4-FH) or 4-nitrobenzoic hydrazide (4-NH) and NN=1,10-phenanthroline (phen), 4-4'-dimethoxy-2-2'-bipyridine (dmb) or 2,2-bipyridine (bipy) were synthesized and characterized using various spectroscopic methods. The X-ray structural analysis of one representative compound indicates that the geometry around the copper ion is distorted octahedron, in which the ion is coordinated to hydrazide via the terminal nitrogen and the carbonyl oxygen, and to heterocyclic bases via their two nitrogen atoms. Two perchlorate anions occupy the apical positions, completing the coordination sphere. The cytotoxic activity of compounds was investigated in three tumor cell lines (K562, MDA-MB-231 and MCF-7). Concerning K562 cell line, the complexes with 1,10-phenanthroline exhibit high cytotoxic activity and are more active than carboplatin, free ligands and [Cu(phen)]. Considering the cytotoxicity results, further investigations for the compounds [Cu(4-FH)(phen)(ClO)] I and [Cu(4-NH)(phen)(ClO)]∙HO III were performed. Flow cytometric analysis revealed that these complexes induce apoptotic cell death in MDA-MB-231 cell line and bind to DNA with K values of 4.38×10 and 2.62×10, respectively. These compounds were also evaluated against wild type Mycobacterium tuberculosis (ATCC 27294) and exhibited antimycobacterial activity, displayed MIC values lower than those of the corresponding free ligands.

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“…By growing Ag NPs on the surface of GO, several groups using different approaches have synthesized GO-Ag NP and rGO-Ag NP nanocomposites with significantly improved antibacterial activities when compared to GO and Ag NPs taken separately. [123][124][125]128,131,134,137,147,172,[177][178][179][180][181][182][183][184][185][186][187] The enhanced antimicrobial activity of GO-Ag NP nanocomposites is attributed to the presence of Ag NPs. Additionally, the high concentration of oxygenated groups confers on GO-Ag NPs sheets the versatility to bind to solid surfaces via covalent and non-covalent interactions, thus providing multiple opportunities to develop multifunctional materials with antimicrobial activity.…”

Section: Other Modified Graphene Matricesmentioning

confidence: 99%

Antibacterial activity of graphene-based materials

2016

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Synthesis, crystal structure and action on Escherichia coli by microcalorimetry of copper complexes with 1,10-phenanthroline and amino acid

Cited by 25 publications

References 42 publications

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

Antibacterial activity of graphene-based materials

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