Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

Nfor, Emmanuel N.; Husian, Ahmad; Majoumo-Mbe, Félicité; Njah, Innocent N.; Offiong, Offiong E.; Bourne, Susan A.

doi:10.1016/j.poly.2013.07.028

Cited by 71 publications

(34 citation statements)

References 47 publications

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“…Elemental analysis of the ligand was in good agreement with literatures values [1]. The molecular ion peak appeared at m/z 286.1 (M + Na) and the (M + H) ion at m/z 264.2.…”

Section: Elemental Analysessupporting

confidence: 88%

“…A single x-ray analysis performed on APN (Figure 4) confirmed the proposed structure of the hydralazine Schiff base showing clearly the exocyclic C=N double bond (bond length 1.308 A˚) of the hydralazine moiety [1] [21] and the N-H bond of bond length 0.918 A˚ [19] 3.5. Activity of Compounds on Microfilariae/Macrofilariae and Cytotoxicity APN was screened on the juvenile form of the O. ochengi beginning at the highest compound concentration of 20 µg/mL.…”

Section: X-ray Datamentioning

confidence: 77%

“…Schiff bases of hydralazine (hydrazones) have shown important medicinal properties including antifungal activities [1] [2], antimicrobial properties [3], antihypertensive agents [4], carbonyl scavenger and antiapoptotic activities [5], luminescence properties [6]. Hydrazones have been reported to be less toxic than hydrazines from which they are derived since the-NH 2 group is blocked [7] [8].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Yong¹,

Majoumo-Mbe²,

Samje³

et al. 2016

IJOC

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The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1 H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC 50 values of 0.3125 µg/mL on microfilaria and 10 µg/mL on adult worms compared to the standard drug, ivermectin.

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“…Elemental analysis of the ligand was in good agreement with literatures values [1]. The molecular ion peak appeared at m/z 286.1 (M + Na) and the (M + H) ion at m/z 264.2.…”

Section: Elemental Analysessupporting

confidence: 88%

Section: X-ray Datamentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Yong¹,

Majoumo-Mbe²,

Samje³

et al. 2016

IJOC

Self Cite

View full text Add to dashboard Cite

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“…Hydralazine hydrochloride is a powerful vasodilator that has been used for several years in the treatment of ambulatory patients with primary hypertension of moderate severity [2,3]. It acts as an e ective arteriolar dilator and is used in the treatment of congestive heart failure [4].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of (E)-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine hydrochloride–ethanol (1/1), C₁₅H₁₇ClN₄OS

El‐Faham

Ghabbour

2016

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Recently, there has been considerable effort in the ability of adenine to form complexes with nickel. Therefore, our studies have been done on the synthesis of a magnetically recoverable nanocatalyst using complex formation of adenine with nickel.…”

Section: Introductionmentioning

confidence: 99%

Ni(II)‐Adenine complex coated Fe₃O₄ nanoparticles as high reusable nanocatalyst for the synthesis of polyhydroquinoline derivatives and oxidation reactions

Tamoradi

Ghadermazi

Ghorbani‐Choghamarani

2017

Applied Organom Chemis

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In the present study, Fe 3 O 4 nanoparticles were prepared via simple and versatile procedure. Then, a novel and green catalyst was synthesized by the immobilization of Ni on Fe 3 O 4 nanoparticles coated with adenine. The activity of this nanostructure compound was examined for the oxidation of sulfides, oxidative coupling of thiols and synthesis of polyhydroquinolines. The prepared catalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma optical emission spectroscopy (ICP-OES), X-ray Diffraction (XRD), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM) measurements. This organometallic catalyst was recovered by the assistance of an external magnetic field from the reaction mixture and reused for seven continuous cycles without noticeable change in its catalytic activity.

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Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

Cited by 71 publications

References 47 publications

Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Crystal structure of (E)-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine hydrochloride–ethanol (1/1), C₁₅H₁₇ClN₄OS

Ni(II)‐Adenine complex coated Fe₃O₄ nanoparticles as high reusable nanocatalyst for the synthesis of polyhydroquinoline derivatives and oxidation reactions

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Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

Cited by 71 publications

References 47 publications

Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Crystal structure of (E)-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine hydrochloride–ethanol (1/1), C15H17ClN4OS

Ni(II)‐Adenine complex coated Fe3O4 nanoparticles as high reusable nanocatalyst for the synthesis of polyhydroquinoline derivatives and oxidation reactions

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Product

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Crystal structure of (E)-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine hydrochloride–ethanol (1/1), C₁₅H₁₇ClN₄OS

Ni(II)‐Adenine complex coated Fe₃O₄ nanoparticles as high reusable nanocatalyst for the synthesis of polyhydroquinoline derivatives and oxidation reactions