Synthesis, crystal structure and magnetism of three novel copper(II) complexes with pyrazole-based ligands

Santos, Igor F.; Guedes, Guilherme P.; Mercante, Luiza A.; Bernardino, Alice M. R.; Vaz, Maria G. F.

doi:10.1016/j.molstruc.2011.12.036

Cited by 16 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnostic peak for the CH=N vibration appears in the range of 1612-1649 cm −1 , in agreement with other related imine heterocyclic compounds [17,19,33,34] . The ν(C=N) corresponding to the breathing or ring stretching modes of pyrazole ring were observed (Table 1) at 1509-1602 cm −1 [13,[35][36][37][38][39] . Although some b a [40,41] , came from the disappearance of the ν(NH 2 ) bands due to the asymmetric and symmetric stretch of the 3-aminopyrazole starting material and by the presence of N-H peak absorption as a broad band between 3205-3239 cm −1 [18] .…”

Section: Resultsmentioning

confidence: 99%

Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

Iglesias¹,

Miranda-Soto²,

Pompa-Monroy³

et al. 2019

pharmaceutical-sciences

View full text Add to dashboard Cite

Treatment of infectious diseases is an ever-increasing problem owing to the growing number of multi-drug resistant pathogens. Nosocomial infections are on the rise due to antibiotic-resistant microorganisms, which have led to increased morbidity and mortality in many hospitals. Cancer is a major disease worldwide [1] ; colorectal cancer particularly, is the second leading cause of death by cancer in Western countries and has one of the highest mortality rates in both men and women. These cancer patients are especially susceptible to nosocomial infections; as a result of their immunosuppressed systems (due to the treatments associated with illness); which in turn leads to prolonged stays, disability and economic burden [2,3]. Therefore, the search for novel compounds that displayed a broad range of therapeutic activities that can address these major health problems is of outmost importance [4]. New therapeutic drugs that contain a heterocyclic core are on the forefront of pharmaceutical research [5,6]. Pyrazoles, (1,2-azoles) have proven to be a remarkable scaffold for the synthesis of biologically active compounds [7-9] thanks to their wide range of medical applications that center mainly on antimicrobial [10-12] , antifungal [8,12,13] , antiinflammatory [7] , analgesic, and anxiolytic activities [13,14]. Some pyrazole derivatives have also shown antitumor activities towards several cancer cell lines, including leukemia (K562), HeLa cervix adenocarcinoma and Fem-x melanoma [14]. Consequently, in recent years pyrazole-base compounds have become a target of great interest.

show abstract

Section: Resultsmentioning

confidence: 99%

Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

Iglesias¹,

Miranda-Soto²,

Pompa-Monroy³

et al. 2019

pharmaceutical-sciences

View full text Add to dashboard Cite

show abstract

“…In addition, owing to its presence in many metalloproteins, Cu is ubiquitous in various biological systems. Cu 2+ -based pyrazole as well as its derivative complexes have been studied for several years because of their remarkable properties both in the solid state 15,[24][25][26] and in solution. 27,28 The pioneering work by Yang and coworkers demonstrated the great potential of a Cu complex, namely [Cu(tpp)$H 2 O] 2n [Htpp ¼ 1-(4-tetrazol-5 00 -yl)benzyl-3-(pyraziny-l)pyrazole], in the detection of acetone and Fe 3+ ions through uorescence quenching.…”

Section: Introductionmentioning

confidence: 99%

A fluorescent Cu(ii) complex as a dual functional sensor for selective and sensitive detection of acetone and Cd(ii) pollutants

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The versatility of pyrazole and its derivatives allows the formation of various coordination complexes with several metal ions [2], since pyrazole is a better π-donor due to two chemically different nitrogen atoms [3]. 3-(pyridin-2-yl)-pyrazole based ligand has been widely used in coordination chemistry as this molecule can act as chelating ligand [4] and forms various metal complexes with interesting structural characteristics [5].…”

Section: Introductionmentioning

confidence: 99%

Formation of a dinuclear copper(II) complex through the cleavage of C<private-char description='Single_Bond' name='Single_Bond' value='Single_Bond'/>N bond of 1-benzoyl-3-(pyridin-2-yl)-1H-pyrazole

Shardin¹,

Pui²,

Yamin³

et al. 2014

AIP Conference Proceedings

View full text Add to dashboard Cite

Abstract.A simple mononuclear octahedral copper(II) complex was attempted from the reaction of three moles of 1-benzoyl-3-(pyridin-2-yl)-1H-pyrazole and one mole of copper(II) perchlorate hexahydrate in methanol. However, the product of the reaction was confirmed to be a dinuclear copper(II) complex with μ-{3-(pyridin-2-yl)-pyrazolato} and 3-(pyridin-2-yl)-1H-pyrazole ligands attached to each of the Cu(II) centre atom. The copper(II) ion assisted the cleavage of the C benzoyl -N bond afforded a 3-(pyridin-2-yl)-1H-pyrazole molecule. Deprotonation of the 3-(pyridin-2-yl)-1H-pyrazole gave a 3-(pyridin-2-yl)-pyrazolato, which subsequently reacted with the Cu(II) ion to give the {3-(pyridin-2-yl)-pyrazolato}{3-(pyridin-2-yl)-1H-pyrazole}Cu(II) product moiety. The structure of the dinuclear complex was confirmed by x-ray crystallography. The complex crystallized in a monoclinic crystal system with P2(1)/n space group and cell dimensions of a = 12.2029(8) Å, b = 11.4010(7) Å, c = 14.4052(9) Å and β = 102.414(2) o . The compound was further characterized by mass spectrometry, CHN elemental analysis, infrared and UV-visible spectroscopy and the results concurred with the x-ray structure. The presence of d-d transition at 671 nm (ε = 116 dm 3 mol -1 cm -1 ) supports the presence of Cu(II) centres.

show abstract

Synthesis, crystal structure and magnetism of three novel copper(II) complexes with pyrazole-based ligands

Cited by 16 publications

References 33 publications

Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

A fluorescent Cu(ii) complex as a dual functional sensor for selective and sensitive detection of acetone and Cd(ii) pollutants

Formation of a dinuclear copper(II) complex through the cleavage of C<private-char description='Single_Bond' name='Single_Bond' value='Single_Bond'/>N bond of 1-benzoyl-3-(pyridin-2-yl)-1H-pyrazole

Contact Info

Product

Resources

About