Synthesis, Crystal Structure, Quantum Chemical Calculations, DNA Interactions, and Antimicrobial Activity of [Ag(2-amino-3-methylpyridine)₂]NO₃ and [Ag(pyridine-2-carboxaldoxime)NO₃]

Abstract

[Ag(2-amino-3-methylpyridine)(2)]NO(3) (1) and [Ag(pyridine-2-carboxaldoxime)NO(3)] (2) were prepared from corresponding ligands and AgNO(3) in water/ethanol solutions, and the products were characterized by IR, elemental analysis, NMR, and TGA. The X-ray crystal structures of the two compounds show that the geometry around the silver(I) ion is bent for complex 1 with nitrate as an anion and trigonal planar for complex 2 with nitrate coordinated. ESI-MS results of solutions of 2 indicate the independent existence in solution of the [Ag(pyridine-2-carboxaldoxime)](+) ion. The geometries of the complexes are well described by DFT calculations using the ZORA relativistic approach. The compounds were tested against 14 different clinically isolated and four ATCC standard bacteria and yeasts and also compared with 17 commonly used antibiotics. Both 1 and 2 exhibited considerable activity against S. lutea , M. lutea , and S. aureus and against the yeast Candida albicans , while 2-amino-3-methylpyridine is slightly active and pyridine-2-carboxaldoxime shows no antimicrobial activity. In addition, the interaction of these metal complexes with DNA was investigated. Both 1 and 2 bind to DNA and reduce its electrophoretic mobility with different patterns of migration, while the ligands themselves induce no change.

A Silver(I) Coordination Polymer Based on a Schiff Base Ligand: Synthesis, Crystal Structure and Luminescence Properties

“…The average distance Ag(1)-N is 2.33Å, similar to previously reported values [21]. The distance Ag(1)-O is 2.604Å, thus the nitrate is only weakly coordinated to the silver ion [22,23] Table 3. Weak C-H···O hydrogen bond interactions (Å and deg) in the crystal structure of 1.…”

Antibacterial Behavior of Pyridinecarboxylatesilver(I) Complexes

“…[1][2][3][4][5][6] Nonetheless, it is know that the type of atom coordinated to Ag(I) and the properties of the resulting bond are both crucial factors for the effectiveness of the silver complexes. Despite numerous investigations related to the topic, the underlying mechanisms and biological activity are not well understood.…”

“…[1][2][3][4][5][6] Nonetheless, it is know that the type of atom coordinated to Ag(I) and the properties of the resulting bond are both crucial factors for the effectiveness of the silver complexes. [1][2][3][4][5][6][7] Although there is consensus that the structureactivity relationship is important in the display of antimicrobial properties, investigations thus far have not been able to provide a general conclusion since the antibacterial activity of the complexes studied depends on the type of bacteria tested. [6,7] Investigations on silver complexes to date have attributed their enhanced antimicrobial properties to distinctive weak Ag-O and Ag-N bonds in their structure.…”

Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates

“…Silver compounds have mainly been studied for their widely known antibacterial effect; in fact, silver nitrate and certain silver complexes are still used against local infections [1][2][3]. From this perspective, compounds with Ag kernels have recently been prepared and studied, including examples containing Ag-N [4][5][6][7], Ag-O [8][9][10] and Ag-S [11][12][13][14][15] bonds and some with other additional bonds. In previous papers, we have contributed [14,15] to the study of Ag-S by preparing compounds of the type [Ag (HL)], [Ag 2 …”