Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells

Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

“…thiazole and 1,3,4-thiadiazole have antitumor activity with excellent IG50 and IC50 as depicted in Figure 1 [33][34][35][36][37]. In view of these facts, we report herein the synthesis of a new series of thiazoles and 1,3,4-thiadiazoles bearing indole moiety for the examination of their antitumor activity against the MCF-7 human breast carcinoma cell line.…”

“…In light of these facts, we have synthesized some new thiazole, dihydropyrido [3,2-e] [1,2,4]triazolo [4,3-a]pyrimidine and 1,3,4-thiadiazole derivatives using 3-acetylindole as a common precursor and screened these compounds for their anticancer activities. A literature survey showed that many derivatives of thiazole and 1,3,4-thiadiazole have antitumor thiazole and 1,3,4-thiadiazole have antitumor activity with excellent IG50 and IC50 as depicted in Figure 1 [33][34][35][36][37]. In view of these facts, we report herein the synthesis of a new series of thiazoles and 1,3,4-thiadiazoles bearing indole moiety for the examination of their antitumor activity against the MCF-7 human breast carcinoma cell line.…”

Synthesis, Characterization and Antimicrobial Activity of Heterocyclic Azodyes Derived from Thiadiazole

“…In this regard, a number of studies have been devoted to the characterization, purification and application of azo dyes as antibacterial agents 12,13 . 1,3,4-Thiadiazole derivatives exhibits a broad spectrum of biocidal activities possibly due to the presence of toxophoric -N-C-S moiety 14 .…”

The synthesis and antitubercular activity of substituted hydrazone,2-pyrazoline-5-one and 2-isoxazoline-5-one derivatives possessing 1,3,4-thiadiazole moiety

“…Therefore, the identification of new compounds for the treatment of tuberculosis is an important under taking in medicinal chemistry research. 1,3,4-Thiadiazole derivatives have received much attention due o their versatile biological activities as antibacterial (3)(4)(5), antitubercular (6-10), antifungal (11), antiviral (12,13), anticancer (3,(14)(15)(16)(17), antiproliferative (18), antiinflammatory, analgesic and antipyretic (19). Pyrazolinones have also shown various biological activities (20)(21)(22).…”