A mild and green protocol was developed for three-component, one pot synthesis of 3,4-dihydropyrimidin-2(1H)-thione derivatives in a deep eutectic solvent (DES) without the use of a catalyst or any other additive.DES based on choline chloride (ChCl) and urea offered high reaction yield and was proper for a wide range of aromatic aldehydes. In addition, after 3,4-dihydropyrimidin-2(1H)-thione synthesis, DES could be easily recycled and reused five times without any obvious changes in catalytic activity. In general, the procedure offers a number of benefits, including clean reaction profile, avoiding the use of typical toxic catalysts, an easy workup procedure, short reaction times, and low prices.